349-56-4 Usage
General Description
3-Methoxy-5-(trifluoromethyl)phenol is a chemical compound that is commonly used as a synthesis intermediate in the manufacturing of pharmaceuticals and other organic compounds. It is a phenolic compound with a methoxy group and a trifluoromethyl group attached to the benzene ring. 3-METHOXY-5-(TRIFLUOROMETHYL)PHENOL has potential applications in the fields of medicine, agriculture, and material science due to its unique structure and properties. Research has shown that 3-Methoxy-5-(trifluoromethyl)phenol may have antioxidant, antibacterial, and antifungal properties, making it a potentially valuable ingredient in various commercial products. However, further studies are needed to fully understand its potential uses and effects.
Check Digit Verification of cas no
The CAS Registry Mumber 349-56-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 349-56:
(5*3)+(4*4)+(3*9)+(2*5)+(1*6)=74
74 % 10 = 4
So 349-56-4 is a valid CAS Registry Number.
349-56-4Relevant articles and documents
Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides
Kang, Qi-Kai,Li, Ke,Li, Yuntong,Lin, Yunzhi,Shi, Hang,Xu, Lun
supporting information, p. 20391 - 20399 (2021/08/13)
Nucleophilic aromatic substitution (SNAr) is a powerful strategy for incorporating a heteroatom into an aromatic ring by displacement of a leaving group with a nucleophile, but this method is limited to electron-deficient arenes. We have now established a reliable method for accessing phenols and phenyl alkyl ethers via catalytic SNAr reactions. The method is applicable to a broad array of electron-rich and neutral aryl fluorides, which are inert under classical SNAr conditions. Although the mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), experimental data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, we isolated a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized carbon bearing both a nucleophile and a leaving group.
