34906-86-0Relevant articles and documents
One-pot route to new α,α-difluoroamides and α-ketoamides
Singh, Rajendra P.,Shreeve, Jean'ne M.
, p. 6063 - 6065 (2003)
New α,α-difluoroamides (4a-d, 6a-d) and α-ketoamides (5a-d, 7a-d) result from one-pot reactions of α-ketoacids, RCOCO2H (R = C6H5, CH3, CH3CH2, thienyl) (1a-d) with bis(2-methoxyethyl)aminosulfur trifluoride [(CH3-OCH2CH2)2NSF3] (2) (Deoxofluor) or diethylaminosulfur trifluoride [(CH3CH2)2NSF3)] (3) (DAST). Product yields depend on reaction times and the ratio of reagents used. Longer reaction times (～36 h) with a 1:2 ratio of α-ketoacids and 2 or 3 gave major yields of the α,α-difluoroamides, and shorter reaction times (～1 h) produced α,α-ketoamides as the major products. Reactants in a 1:1 ratio resulted in α-ketoamides only.
Diversification of α-ketoamides: Via transamidation reactions with alkyl and benzyl amines at room temperature
Junaid, Qazi Mohammad,Kandasamy, Jeyakumar,Popuri, Sureshbabu,Sabiah, Shahulhameed,Singh, Shweta
, p. 7134 - 7140 (2021/08/30)
A wide range of N-tosyl α-ketoamides underwent transamidation with various alkyl amines in the absence of a catalyst, base, or additive. On the other hand, transamidation in N-Boc α-ketoamides was achieved in the presence of Cs2CO3. The reactions proceede
Ligand-free Zn-catalyzed double carbonylation of aryl iodides with secondary amines: A simple and efficient approach to access α-ketoamides
Chidara, Sridhar,Mogili, Padma,Pitti, Vimala,Sarma Vangala, Markandeya
supporting information, (2021/12/22)
Herein, we report a Zinc catalyzed double carbonylation of aryl iodides with secondary amines under CO pressure for the synthesis of α-ketoamides in good to excellent yields. This methodology provides a simple and economic approach to derivatize useful α-
