34916-78-4

Basic information

• Product Name: 5,6-DIMETHYL-PYRIMIDIN-4-OL
• Synonyms: 5,6-DIMETHYL-PYRIMIDIN-4-OL;4(1H)-Pyrimidinone, 5,6-dimethyl- (9CI);5,6-dimethyl-4-pyrimidinol(SALTDATA: FREE);4(3H)-PyriMidinone, 5,6-diMethyl-;5,6-Dimethyl-4-pyrimidinol;5,6-dimethyl-4(3H)-Pyrimidinone;5,6-Dimethylpyrimidin-4(3H)-one
• CAS NO: 34916-78-4
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• Product Categories: PYRIMIDINE
• Mol File: 34916-78-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 202-204 °C
• Boiling Point: 255°Cat760mmHg
• Flash Point: 108°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 0.0104mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.62±0.50(Predicted)
• CAS DataBase Reference: 5,6-DIMETHYL-PYRIMIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIMETHYL-PYRIMIDIN-4-OL(34916-78-4)
• EPA Substance Registry System: 5,6-DIMETHYL-PYRIMIDIN-4-OL(34916-78-4)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 34916-78-4(Hazardous Substances Data)

Usage

Description

5,6-DIMETHYL-PYRIMIDIN-4-OL is an organic compound belonging to the pyrimidine family, characterized by its fused six-membered heterocyclic structure. It is a white crystalline solid with the molecular formula C6H8N2O. 5,6-DIMETHYL-PYRIMIDIN-4-OL is known for its potential applications in the pharmaceutical industry, particularly in the development of therapeutic agents.

Uses

Used in Pharmaceutical Industry:
5,6-DIMETHYL-PYRIMIDIN-4-OL is used as a key intermediate compound for the synthesis of pyrimidine derivatives, which are essential in the treatment of various medical conditions. One of its primary applications is in the preparation of pyrimidine derivatives for the treatment of α1-antitrypsin deficiency, a genetic disorder that affects the lungs and liver.
α1-antitrypsin deficiency is a condition characterized by the lack or reduced function of the α1-antitrypsin protein, which is essential for protecting the lungs from damage caused by an enzyme called neutrophil elastase. The pyrimidine derivatives synthesized using 5,6-DIMETHYL-PYRIMIDIN-4-OL have shown potential in modulating the activity of this enzyme, thereby offering a therapeutic approach to managing the symptoms and progression of the disease.

InChI:InChI=1/C6H8N2O/c1-4-5(2)7-3-8-6(4)9/h3H,1-2H3,(H,7,8,9)

Upstream product

• 28456-54-4 5,6-dimethyl-2-thiouracil 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 6313-33-3 formamidine hydrochloride 
• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 89532-63-8 N-(3,4-dimethyl-isoxazol-5-yl)-formamide 
• 64-17-5 ethanol 
• 463-52-5 formamidine 
• 1780-32-1 2,4-dichloro-5,6-dimethylpyrimidine 
• 71-36-3 butan-1-ol 

Downstream Products

• 67434-65-5 4-chloro-5,6-dimethylpyrimidine 

Relevant articles and documents

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Process for preparing 4-hydroxypyrimidine

A process for preparing a 4-hydroxypyrimidine of Formula III: STR1 wherein R1 and R2 each represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms or an aralkyl group having 2 to 10 carbon atoms, and R4 represents hydrogen an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms, an aralkyl group having 7 to 10 carbon atoms or an aryl group having 6 to 10 carbon atoms, which comprises subjecting a 3-amino-2-unsaturated carboxylate of Formula I: STR2 wherein R1 and R2 are as defined above and R3 represents an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms or an aralkyl group having 7 to 10 carbon atoms, and a carboxylic acid amide of Formula II: wherein R4 is as defined above, to reaction with each other in the presence of a base.