34923-96-1

Basic information

• Product Name: N-(4-methylphenyl)-N-(4-quinazolinyl)amine
• Synonyms: N-(4-methylphenyl)-N-(4-quinazolinyl)amine
• CAS NO: 34923-96-1
• Molecular Formula: C₁₅H₁₃N₃
• Molecular Weight: 235.28382
• Mol File: 34923-96-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-methylphenyl)-N-(4-quinazolinyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)-N-(4-quinazolinyl)amine(34923-96-1)
• EPA Substance Registry System: N-(4-methylphenyl)-N-(4-quinazolinyl)amine(34923-96-1)

Safety Data

• Hazardous Substances Data: 34923-96-1(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 106-49-0 p-toluidine 
• 28144-70-9 anthranilic acid amide 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 
• 491-36-1 4-Hydroxyquinazoline 
• 1276665-99-6 C₈H₅Cl₅N₅OP₃ 
• 36185-83-8 N'-(2-cyanophenyl)-N,N-dimethylimidoformamide 
• 1885-29-6 anthranilic acid nitrile 

Relevant articles and documents

Catalyst and solvent switched divergent C-H functionalization: Oxidative annulation of: N -aryl substituted quinazolin-4-amine with alkynes

The development of site-selective C-H functionalizations/annulations is one of the most challenging practices in synthetic organic chemistry particularly for substrates bearing several similarly reactive C-H bonds. Herein, we describe catalyst and solvent controlled ortho/peri site-selective oxidative annulation of C-H bonds of N-aryl substituted quinazolin-4-amines with internal alkynes. The ortho C-H selective annulation was observed using Pd-catalyst in DMF to give indole-quinazoline derivatives, while, Ru-catalyst in PEG-400 favoured the peri C-H bond annulation exclusively to furnish pyrido-quinazoline derivatives.

One-pot multi component synthesis of 4-arylaminoquinazolines in the presence of sodium 30-tungstopentaphosphate

A new multi-component synthesis of 4-arylaminoquinazolines from the reaction of 2-aminobenzamide, orthoesters and substituted anilines in presence of catalytic amounts of sodium 30-tungstopentaphosphate, so-called Preyssler heteropolyacid, is reported. The effects of solvent, amount of catalyst and aniline and reaction time were studied. Optimum conditions for synthesis of 4-arylaminoquinazolines have been obtained.

Synthesis of 4-arylaminoquinazolines via 2-amino-N-arylbenzamidines

A new synthesis of twelve 4-arylaminoquinazolines from 2-amino-N- arylbenzamidines and formic acid is described. The entering amidines were obtained in the reaction of anthranilonitrile with 50% molar excess of aromatic amines anhydrous aluminium chloride