349404-17-7

Basic information

• Product Name: 2-phenyl-N-((pyridin-3-yl)methyl)acetamide
• Synonyms: 2-phenyl-N-((pyridin-3-yl)methyl)acetamide
• CAS NO: 349404-17-7
• Molecular Weight: 226.278
• Mol File: 349404-17-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-phenyl-N-((pyridin-3-yl)methyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-N-((pyridin-3-yl)methyl)acetamide(349404-17-7)
• EPA Substance Registry System: 2-phenyl-N-((pyridin-3-yl)methyl)acetamide(349404-17-7)

Safety Data

• Hazardous Substances Data: 349404-17-7(Hazardous Substances Data)

Upstream product

• 3731-52-0 3-Aminomethylpyridine 
• 103-82-2 phenylacetic acid 
• 104-01-8 4-Methoxyphenylacetic acid 
• 60-12-8 2-phenylethanol 

Relevant articles and documents

Highly efficient preparation of amides from aminium carboxylates using N-(p-toluenesulfonyl) imidazole

Treatment of aminium carboxylates with N-(p-toluenesulfonyl)imidazole in the presence of triethylamine in DMF at 100 °C afforded the corresponding amides in good to excellent yields. N-(p-Toluenesulfonyl)imidazole proved to be a highly efficient coupling reagent for the preparation of numerous structurally diverse primary, secondary and tertiary amides.

Zirconium catalyzed amide formation without water scavenging

A scalable homogeneous metal-catalyzed protocol for direct amidation of carboxylic acids is presented. The use of 2–10?mol% of the commercially available Zr(Cp)2(OTf)2·THF results in high yields of amides at moderate temperature, using an operationally convenient reaction protocol that circumvents the use of water scavenging techniques.

N-Heterocyclic carbene-based well-defined ruthenium hydride complexes for direct amide synthesis from alcohols and amines under base-free conditions

Readily synthesized, well-defined N-heterocyclic carbene-based ruthenium(II) hydride complexes were developed for amide synthesis from alcohols and amines under base-free conditions. Diverse amides were synthesized in fair-to-excellent yields. In the case of secondary amines, where direct dehydrogenative amidation is not feasible, a catalytic amount of a base was required to promote the transamidation of esters, which are byproducts of alcohol dimerization.