349553-98-6 Usage
Description
DL-MEVALONOLACTONE-4,4,5,5-D4, also known as (±)-Mevalonolactone-4,4,5,5-d4, is a labeled version of D,L-Mevalonic Acid Lactone (M339025(P)). It is a metabolite derived from endophytes of the medicinal plant Erythrina crista-galli. DL-MEVALONOLACTONE-4,4,5,5-D4 is characterized by its unique molecular structure and stable isotope labeling, which makes it a valuable compound for various applications in research and pharmaceutical industries.
Uses
Used in Pharmaceutical Research:
DL-MEVALONOLACTONE-4,4,5,5-D4 is used as a research compound for studying the metabolic pathways and biological activities of D,L-Mevalonic Acid Lactone. Its stable isotope labeling allows for the tracking and analysis of its interactions with various biological systems, providing insights into its potential therapeutic applications.
Used in Drug Development:
DL-MEVALONOLACTONE-4,4,5,5-D4 is used as a starting material or intermediate in the synthesis of novel drug candidates. Its unique structure and stable isotope labeling make it an attractive candidate for the development of new pharmaceuticals targeting various diseases and conditions.
Used in Metabolic Studies:
DL-MEVALONOLACTONE-4,4,5,5-D4 is used as a tracer compound in metabolic studies, particularly in the investigation of the mevalonate pathway. Its stable isotope labeling enables researchers to monitor the metabolic fate of this compound and its role in various cellular processes.
Used in Analytical Chemistry:
DL-MEVALONOLACTONE-4,4,5,5-D4 is used as an internal standard or reference compound in analytical chemistry, particularly in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Its stable isotope labeling provides a reliable reference for the accurate quantification and identification of related compounds in complex biological samples.
Used in the Development of Diagnostic Tools:
DL-MEVALONOLACTONE-4,4,5,5-D4 can be used in the development of diagnostic tools for the detection and monitoring of diseases and conditions related to the mevalonate pathway. Its stable isotope labeling allows for the sensitive and specific detection of this compound and its metabolites in biological samples, potentially leading to the development of new diagnostic assays and tests.
Check Digit Verification of cas no
The CAS Registry Mumber 349553-98-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,9,5,5 and 3 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 349553-98:
(8*3)+(7*4)+(6*9)+(5*5)+(4*5)+(3*3)+(2*9)+(1*8)=186
186 % 10 = 6
So 349553-98-6 is a valid CAS Registry Number.
349553-98-6Relevant articles and documents
Practical enantioselective synthesis of fully deuterated (R)-mevalonolactone
Eguchi, Tadashi,Watanabe, Eriko,Kakinuma, Katsumi
, p. 6035 - 6038 (2007/10/03)
Practical enantioselective synthetic method of fully deuterated (R)-mevalonolactone has been developed based upon Sharpless asymmetric epoxidation. (R)-Mevalonolactone-d9 1 was prepared on multi-gram scale in seven steps in 17% overall yield.
Diacetone-glucose architecture as a chirality template. Part 9. Enantioselectiye synthesis of (R)-mevalonolactone and (R)-[2H9]mevalonolactone on carbohydrate template
Kishida, Masashi,Yamauchi, Noriaki,Sawada, Keiju,Ohashi, Yuji,Eguchi, Tadashi,Kakinuma, Katsumi
, p. 891 - 895 (2007/10/03)
A highly enantioselective synthetic methodology for (R)-mevalonolactone has been developed based upon the chirality-transcription approach using a chiral template, diacetone-D-glucos-3-ulose 2. (R)-Mevalonolactone 1a is prepared from ketone 2 in 5 steps in 11% overall yield. This methodology is further applied to the synthesis of fully deuteriated (R)-[2H9]mevalonolactone 1b starting from ketone 2 and methyl [2H7]senecioate 7.
