34956-85-9Relevant articles and documents
Efficient Syntheses of Biologically Important (S)-2-Amino-8-oxodecanoic Acid (Aoda) and Homologues
Kim, Sanghee,Kim, Eun-Young,Ko, Hyojin,Jung, Young Hoon
, p. 2194 - 2198 (2003)
The efficient and practical asymmetric syntheses of the biologically important (S)-2-amino-8-oxodecanoic ester and its homologues have been achieved employing the Schoellkopf chiral auxiliary. Carbon-carbon bond formation between the appropriate alkyl bromide and the LDA generated anion of the Schoellkopf auxiliary, followed by hydrolysis provided the desired methyl ester of a long-chained keto amino acid in high yield with high selectivity.
Ring-closing metathesis in the synthesis of biologically active peptidomimetics of apicidin A
Deshmukh, Prashant H.,Schulz-Fademrecht, Carsten,Procopiou, Panayiotis A.,Vigushin, David A.,Coombes, R. Charles,Barrett, Anthony G. M.
, p. 175 - 183 (2008/02/03)
Syntheses of novel 16-membered macrocyclic peptidomimetics are reported, which employ iterative peptide coupling followed by high yielding ring-closing metathesis (RCM) as the key cyclization step. The target macrocyclic compounds include examples contain