34961-64-3

Basic information

• Product Name: 3-(4-FORMYLPHENYL)PROPANOIC ACID
• Synonyms: 3-(4-FORMYLPHENYL)PROPANOIC ACID;3-(4-ForMylphenyl)propionic acid, 96%;4-Formylbenzenepropanoic acid
• CAS NO: 34961-64-3
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• Mol File: 34961-64-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: ca 136℃
• Boiling Point: 356.916 °C at 760 mmHg
• Flash Point: 183.847 °C
• Appearance: /
• Density: 1.228 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• PKA: 4.56±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-(4-FORMYLPHENYL)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FORMYLPHENYL)PROPANOIC ACID(34961-64-3)
• EPA Substance Registry System: 3-(4-FORMYLPHENYL)PROPANOIC ACID(34961-64-3)

Safety Data

• Hazardous Substances Data: 34961-64-3(Hazardous Substances Data)

Usage

Description

3-(4-FORMYLPHENYL)PROPANOIC ACID, also known as 4'-formylphenylacetic acid, is an organic compound with the molecular formula C10H10O3. It is a derivative of propanoic acid, featuring a formyl group attached to a phenyl ring. 3-(4-FORMYLPHENYL)PROPANOIC ACID is characterized by its potential reactivity and structural diversity, making it a versatile building block in the synthesis of various chemical and pharmaceutical products.

Uses

Used in Pharmaceutical Industry:
3-(4-FORMYLPHENYL)PROPANOIC ACID is used as an intermediate in the manufacture of pharmaceuticals for its ability to be further modified and incorporated into the synthesis of various drug molecules. Its unique structure allows for the development of new therapeutic agents with potential applications in treating a range of medical conditions.

InChI:InChI=1/C10H10O3/c11-7-9-3-1-8(2-4-9)5-6-10(12)13/h1-4,7H,5-6H2,(H,12,13)

Upstream product

• 23359-08-2 4-formylcinnamic acid 
• 66885-68-5 (E)-p-formylcinnamic acid 
• 3984-22-3 2-vinyl-1,3-dioxolane 
• 1122-91-4 4-bromo-benzaldehyde 
• 56703-34-5 3-[4-(hydroxymethyl)phenyl]propanoic acid 
• 58045-41-3 methyl 3‐(4‐formylphenyl)acrylate 
• 43153-07-7 2-(4-formylphenyl)propanoic acid 
• 177352-24-8 (E)-3-(4-dimethoxymethyl-phenyl)-acrylic acid 
• 445483-72-7 3-(4-formyl-phenyl)-propionic acid ethyl ester 
• 87199-17-5 4-formylphenylboronic acid, 
• 79-10-7 acrylic acid 
• 90392-95-3 3-(4'-formylphenyl)propanal 
• 38628-53-4 3-<4-(hydroxymethyl)phenyl>propanol 
• 623-27-8 terephthalaldehyde, 

Downstream Products

• 3179-13-3 3-[4-((E)-2-Nitro-vinyl)-phenyl]-propionic acid 
• 925413-76-9 4-{3-oxo-3-[4-(1-trityl-1H-imidazol-4-ylmethyl)-piperidin-1-yl]-propyl}-benzaldehyde 
• 1018674-56-0 3-[4-({4-[(benzyloxy)carbonyl]-3-[(cyclopentyloxy)carbonyl]piperazin-1-yl}methyl)phenyl]propanoic acid 
• 178313-88-7 p-Nitrophenyl-3-{4-[bis-(4-methoxyphenyl)-methyl]-phenyl}-propionate 
• 197963-40-9 p-Nitrophenyl-3-{4-[bis-(4-methoxyphenyl)-chlormethyl]-phenyl}-propionate 
• 178313-89-8 p-Nitrophenyl-3-{4-[bis-(4-methoxyphenyl)-hydroxymethyl]phenyl}-propionate 
• 910814-05-0 3-{4-[3-oxo-3-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propenyl]-phenyl}-propionic acid 
• 1622313-43-2 4-(3-oxo-3-(3,4,4-trimethyl-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)propyl)benzaldehyde 

Relevant articles and documents

The polymorphism of porphyrin 2D assemblies at the liquid-graphite interface: The effect of a polar solvent additive and a flexible spacer on the face-on and edge-on type molecular arrangements

Self-assembly structures of 5,10,15,20-tetrakis(4-substituted phenyl)porphyrins at the liquid-graphite interface were investigated by scanning tunneling microscopy. We found that the presence of a small amount of a polar solvent, i.e., only 0.5 vol% of octanoic acid in phenyloctane, significantly affected the selective formation of the face-on polymorph over the edge-on one likely due to the solvent-molecule interactions at the 2D interface.

Selective oxoammonium salt oxidations of alcohols to aldehydes and aldehydes to carboxylic acids

The oxidation of alcohols to aldehydes using stoichiometric 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (1) in CH2Cl2 at room temperature is a highly selective process favoring reaction at the carbinol center best able to accommodate a positive charge. The oxidation of aldehydes to carboxylic acids by 1 in wet acetonitrile is also selective; the rate of the process correlates with the concentration of aldehyde hydrate. A convenient and high yield method for oxidation of alcohols directly to carboxylic acids has been developed.

Rhodium(I)-catalyzed 1,4-addition of arylboronic acids to acrylic acid in water: One-step preparation of 3-arylpropionic acids

A practical method for the one-step preparation of 3-arylpropionic acids through rhodium-catalyzed 1,4-addition of arylboronic acids to acrylic acid is reported. The method is applicable to a broad scope of aryl boronic acids and displays a wide functional group tolerance operating in water as the optimal reaction medium. Georg Thieme Verlag Stuttgart · New York.