349626-17-1

Basic information

• Product Name: Acetamide, N-[4-[[(6-methoxy-2-benzothiazolyl)amino]sulfonyl]phenyl]-
• CAS NO: 349626-17-1
• Molecular Formula: C16H15N3O4S2
• Molecular Weight: 377.445
• Mol File: 349626-17-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-[[(6-methoxy-2-benzothiazolyl)amino]sulfonyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-[[(6-methoxy-2-benzothiazolyl)amino]sulfonyl]phenyl]-(349626-17-1)
• EPA Substance Registry System: Acetamide, N-[4-[[(6-methoxy-2-benzothiazolyl)amino]sulfonyl]phenyl]-(349626-17-1)

Safety Data

• Hazardous Substances Data: 349626-17-1(Hazardous Substances Data)

Upstream product

• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 93431-73-3 4-amino-N-(6-methoxybenzo[d]thiazol-2-yl)benzenesulfonamide 

Relevant articles and documents

Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity

The 2-arylsulfonylaminobenzothiazole derivatives 1-27 were prepared using a one step reaction. The in vitro inhibitory activity of the compounds against protein tyrosine phosphatase 1B (PTP-1B) was evaluated. Compounds 4 and 16 are rapid reversible (mixed-type) inhibitors of PTP-1B with IC50 values in the low micromolar range. The most active compounds (4 and 16) were docked into the crystal structure of PTP-1B. Docking results indicate potential hydrogen bond interactions between the nitro group in both compounds and the catalytic amino acid residues Arg 221 and Ser 216. Both compounds were evaluated for their in vivo antihyperglycemic activity in a type 2 diabetes mellitus rat model, showing significant lowering of plasma glucose concentration, during the 7 h post-intragastric administration.

Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain

A series of sulphonamide derivatives (1-11) were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in MES and scPTZ tests. All the compounds were less toxic than the standard drug phenytoin.