34973-08-5 Usage
Description
Gonadorelin acetate, also known as gonadotropin-releasing hormone (GnRH) or luteinizing hormone-releasing hormone (LHRH), is a synthetic decapeptide hormone that mimics the natural gonadotropin-releasing hormone produced by neuroendocrine cells within the hypothalamus. It plays a crucial role in the regulation of the reproductive system by stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland.
Uses
Used in Agricultural and Biological Studies:
Gonadorelin acetate is used as a gonad-stimulating principle for various agricultural and biological studies, including the study of ovulation synchronization in dairy cows. This application aids in enhancing reproductive efficiency and managing the breeding cycles of livestock.
Used in Reproduction Medicine:
In reproduction medicine, gonadorelin acetate is used as a diagnostic agent to assess the function of the hypothalamic-pituitary-gonadal axis. It helps in the diagnosis of conditions related to the reproductive system, such as cryptorchism and ovarian follicular cysts.
Used in Veterinary Medicine:
Gonadorelin acetate is used in veterinary medicine for the synchronization of ovulation, which is essential for managing breeding programs and improving reproductive success in animals.
Used in the Diagnosis of Hypothalamic-Pituitary-Gonadal Axis Function:
Gonadorelin acetate is used as a diagnostic tool to evaluate the function of the hypothalamic-pituitary-gonadal axis, which is crucial for maintaining the body's reproductive and hormonal balance. This application helps in identifying any abnormalities or dysfunctions in the reproductive system.
Indications
Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species.Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.
Biological Activity
Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle- stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (Item No. 23555; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.
Safety Profile
A poison by
intravenous route. Moderately toxic by
ingestion and subcutaneous routes.
Experimental reproductive effects. When
heated to decomposition it emits acrid
smoke and irritating vapors.
Preparation and handling
Gonadorelin (acetate) is supplied as a crystalline solid. A stock solution may be made by dissolving the gonadorelin (acetate) in the solvent of choice. Gonadorelin (acetate) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of gonadorelin (acetate) in ethanol is approximately 0.25 mg/ml and approximately 30 mg/ml in DMSO and DMF. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of gonadorelin (acetate) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of gonadorelin (acetate) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.
Check Digit Verification of cas no
The CAS Registry Mumber 34973-08-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,9,7 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 34973-08:
(7*3)+(6*4)+(5*9)+(4*7)+(3*3)+(2*0)+(1*8)=135
135 % 10 = 5
So 34973-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C55H75N17O13.C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;/m0./s1
