34996-89-9Relevant articles and documents
Optimisation and synthesis of libraries derived from phenolic amino acid scaffolds
Morley
, p. 7405 - 7408 (2000)
Functionalisation of a series of resin bound phenolic amino acids is described, employing Irori technology to produce multidimensional libraries. (C) 2000 Elsevier Science Ltd.
Ring opening with kinetic resolution of azlactones by Ti-TADDOLates
Gottwald, Konstanze,Seebach, Dieter
, p. 723 - 738 (2007/10/03)
The kinetic resolution of azlactones by the Lewis, acid-mediated transfer of an isopropoxide ligand from the chiral ligand sphere of Ti- TADDOLate is described. The reactions proceed with in-situ racemization of the starting material to afford highly enantiomerically enriched N-benzoyl- amino acid isopropylesters (er > 95:5 after recrystallization). The absolute configuration of the major enantiomer of N-benzoyl-phenylalanine isopropyl ester and its analogs with other aromatic substituents was shown to be (S)- (+) when the (R,R)-Ti-TADDOLate was employed. Only benzyl-substituted azlactones can be opened enantioselectively by the method described here.
Composition containing a penem or carbapenem antibiotic
-
, (2008/06/13)
Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.