350-22-1

Basic information

• Product Name: AKOS B018293
• Synonyms: AKOS B018293;ART-CHEM-BB B018293;CHEMBRDG-BB 3018293;(5E)-5-(2-fluorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one;Albb-009167;(5E)-5-(2-fluorobenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one(SALTDATA: FREE);(5Z)-5-(2-fluorobenzylidene)-2-thioxo-thiazolidin-4-one;(5Z)-5-[(2-fluorophenyl)methylene]-2-thioxo-4-thiazolidinone
• CAS NO: 350-22-1
• Molecular Formula: C₁₀H₆FNOS₂
• Molecular Weight: 239.29
• Mol File: 350-22-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 360.7°C at 760 mmHg
• Flash Point: 172°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 2.17E-05mmHg at 25°C
• Refractive Index: 1.706
• CAS DataBase Reference: AKOS B018293(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS B018293(350-22-1)
• EPA Substance Registry System: AKOS B018293(350-22-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 350-22-1(Hazardous Substances Data)

Usage

General Description

AKOS B018293 is a chemical compound that is identified by its CAS number 644996-12-8. It is a urea-based derivative of 4-aminothieno[2,3-d]pyrimidine-6-carboxamide, and is commonly used as a building block in the synthesis of pharmaceutical compounds. It has been investigated for its potential as an antineoplastic and antiviral agent, and is also recognized for its ability to inhibit cyclin-dependent kinases. Its molecular formula is C8H6N4OS, and it has a molecular weight of 202.22 g/mol. AKOS B018293 is classified as a drug intermediate or raw material, and its inclusion in various drug synthesis processes makes it an important compound in the pharmaceutical industry.

InChI:InChI=1/C10H6FNOS2/c11-7-4-2-1-3-6(7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5+

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 1236049-23-2 N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(2-fluorophenylmethylene)-2-thioxo-4-thiazolidinone 
• 1390675-54-3 C₁₆H₁₇FN₂O₃S 
• 1390675-55-4 C₁₉H₁₅FN₂O₃S 
• 1390675-37-2 (Z)-2-(5-(2-fluorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-4-methyl-N-tosylpentanamide 
• 1390675-38-3 (Z)-2-(5-(2-fluorobenzyliden)-4-oxo-4,5-dihydrothiazol-2-ylamino)-3-phenyl-N-tosylpropanamide 
• 1390675-49-6 C₁₁H₈FNOS₂ 

Relevant articles and documents

Three substituted (Z)-5-benzylidene-2-thioxothiazolidin-4-ones: Hydrogen-bonded dimers that can be effectively isolated or linked into chains either by aromatic π-π stacking interactions or by dipolar carbonyl-carbonyl interactions

In each of the isomeric compounds (Z)-5-(2-fluorobenzyl-idene)-2- thioxothiazolidin-4-one, C10H6FNOS2, (I), and (Z)-5-(4-fluorobenzylidene)-2-thioxothiazolidin-4-one, C10H 6FN-OS2, (II), th

Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein

A series of novel rhodanine-based acylsulfonamide derivatives were designed, synthesized, and evaluated as small-molecule inhibitors of anti-apoptotic Bcl-2 protein. These compounds exhibit potent antiproliferative activity in three human tumor cell lines

Synthesis and characterization of (Z)-5-arylmethylidenerhodanines with photosynthesis-inhibiting properties

A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compo