350-39-0

Basic information

• Product Name: p-Nitro-α-fluoroacetophenone
• Synonyms: p-Nitro-α-fluoroacetophenone
• CAS NO: 350-39-0
• Molecular Weight: 183.139
• Mol File: 350-39-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: p-Nitro-α-fluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: p-Nitro-α-fluoroacetophenone(350-39-0)
• EPA Substance Registry System: p-Nitro-α-fluoroacetophenone(350-39-0)

Safety Data

• Hazardous Substances Data: 350-39-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 100-19-6 (4-nitrophenyl)ethanone 
• 1046785-21-0 4-(2-fluoro-1,1-dimethoxyethyl)-4-nitrobenzene 
• 99-81-0 4-Nitrophenacyl bromide 
• 74812-79-6 1-(4-nitrophenyl)-1-trimethylsilyloxyethylene 
• 82961-74-8 5-[hydroxy(4-nitrophenyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 122-04-3 4-nitro-benzoyl chloride 
• 65220-26-0 1-azido-1-(4-nitrophenyl)ethene 
• 100-13-0 4-nitrostyrene 
• 4203-31-0 2-diazo-1-(4-nitrophenyl)ethanone 

Downstream Products

• 1073056-12-8 (R)-2-fluoro-1-(4-nitrophenyl)ethanol 
• 40733-89-9 (+/-)-2-fluoro-1-(4-nitrophenyl)ethanol 

Relevant articles and documents

α-Fluorotricarbonyl Derivatives as Versatile Fluorinated Building Blocks: Synthesis of Fluoroacetophenone, Fluoroketo Ester and Fluoropyran-4-one Derivatives

Fluorinated acyl-Meldrum's acid derivatives were synthesized by electrophilic fluorination of appropriate phenacyl Meldrum's acid substrates using Selectfluor. Reactions with water, ethanol, Grignard, and alkynyllithium reagents gave rise to the correspon

Fluorination of α-bromomethyl aryl ketones with fluorohydrogenate-based ionic liquids

Fluorination of α-bromomethyl aryl ketones using fluorohydrogenate-based ionic liquids as fluorinating reagent is described. Reaction of various α-bromomethyl aryl ketones (1a-g) with fluorohydrogenate-based ionic liquids such as EMIMF·(HF)2.3, PYR13F·(HF)2.3 or PYR14F·(HF)2.3 as a fluoride ion source in anhydrous THF led to the formation of the corresponding α-fluoromethyl aryl ketones (2a-g) in very good yield. Compared to alternative fluorinating agents for this reaction, fluorohydrogenate-based ionic liquids are safer to handle and have the potential to be less expensive and more selective.

Synthesis of enantiopure fluorohydrins using alcohol dehydrogenases at high substrate concentrations

The use of purified and overexpressed alcohol dehydrogenases to synthesize enantiopure fluorinated alcohols is shown. When the bioreductions were performed with ADH-A from Rhodococcus ruber overexpressed in E. coli, no external cofactor was necessary to obtain the enantiopure (R)-derivatives. Employing Lactobacillus brevis ADH, it was possible to achieve the synthesis of enantiopure (S)-fluorohydrins at a 0.5 M substrate concentration. Furthermore, due to the activated character of these substrates, a huge excess of the hydrogen donor was not necessary.