350-97-0

Basic information

• Product Name: 2-fluoro-N-(4-nitrophenyl)benzamide
• Synonyms: 2-fluoro-N-(4-nitrophenyl)benzamide
• CAS NO: 350-97-0
• Molecular Weight: 260.224
• Mol File: 350-97-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-fluoro-N-(4-nitrophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-N-(4-nitrophenyl)benzamide(350-97-0)
• EPA Substance Registry System: 2-fluoro-N-(4-nitrophenyl)benzamide(350-97-0)

Safety Data

• Hazardous Substances Data: 350-97-0(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 393-52-2 2-Fluorobenzoyl chloride 
• 445-29-4 o-fluoro-benzoic acid 

Downstream Products

• 273384-72-8 N-(4-Amino-phenyl)-2-fluoro-benzamide 

Relevant articles and documents

Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments

VEGF/VEGFR-2 signaling plays a critical part in tumor angiogenesis. Inhibition of this pathway has been considered as a promising approach for cancer treatment. In this work, a series of 6,7-dimethoxy-4-anilinoquinazoline derivatives bearing diarylamide moiety were designed, synthesized and evaluated as potent inhibitors of VEGFR-2 kinase. Their in vitro antiproliferation activities against two human cancer cell lines Hep-G2 and MCF-7 have also been determined. Among them, compound 14b exhibited the most potent inhibitory activity against VEGFR-2 with IC50 value of 0.016 ± 0.002 μM and it showed the most potent antiproliferative effect against Hep-G2 and MCF-7 with IC50 values at low-micromolar range. Molecular docking studies revealed that these compounds represented by the most potent compound 14b could bind well to the ATP-binding site of VEGFR-2, which suggested that compound 14b could be a potential anticancer agent targeting VEGFR-2.