35010-98-1Relevant articles and documents
Stereocontrolled [11C]Alkylation of N-Terminal Glycine Schiff Bases To Obtain Dipeptides
Filp, Ulrike,Peko?ak, Aleksandra,Poot, Alex J.,Windhorst, Albert D.
supporting information, p. 5592 - 5596 (2017/10/13)
The use of various quaternary ammonium salts as chiral phase-transfer catalysts allowed effective and stereoselective radiochemical [11C]alkylation to obtain functionalized dipeptides. We herein report a broadly applicable procedure for the asymmetric [11C]alkylation of dipeptides to give labeled N-terminal peptides by using different [11C]alkyl halides. Contended stereoselectivities of the reactions were observed by using 11C-labeled alkyl halides, [11C]methyl iodide and [11C]benzyl iodide, and diastereomeric ratios with different specialized catalysts of 95:5 and 90:10 were achieved, respectively. Accordingly, the straightforward synthesis of enantioenriched compounds should play a vital role in peptide-based radiopharmaceutical development and positron emission tomography imaging.
PEPTIDES-XXXXV. SYNTHESIS OF THE 118-129 FRAGMENT OF A LYSOZYME ANALOGUE
Galpin, I. J.,Kenner, G. W.,Ramage, R.,Thorpe, W. D.
, p. 3037 - 3042 (2007/10/02)
The synthesis of the (118-129) fragment of a Lysozyme analogue was achieved by the fragment coupling approach.The fragments were assembled using the DCCI/HONSu method and the (118-122), (123-126) and (127-129) subfragments were each built up in a stepwise
[8 Homoarginine]luteinizing hormone releasing hormone
Geiger,Koenig,Sandow,Schally
, p. 1526 - 1534 (2007/10/07)
The synthesis and LH releasing activity of [8 homoarginine] LH RH are described. Its biological activity is discussed in relation to that of other analogues with substitutions in position 8. Although in homoarginine the positive charge of the guanidino gr