35042-48-9Relevant articles and documents
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies
Daelemans, Dirk,De Clercq, Erik,Gao, Ping,Ginex, Tiziana,Huang, Boshi,Jiang, Xiangyi,Kang, Dongwei,Liu, Xinyong,Luque, F. Javier,Pannecouque, Christophe,Zhan, Peng,Zhang, Jian
, p. 13604 - 13621 (2021/09/28)
Two series of new pyridyl-bearing fused bicyclic analogues designed to target the dual-tolerant regions of the non-nucleoside reverse transcriptase inhibitor (NNRTI)-binding pocket were synthesized and evaluated for their anti-HIV activities. Several comp
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β
Ortega, Jose Antonio,Arencibia, Jose M.,Minniti, Elirosa,Byl, Jo Ann W.,Franco-Ulloa, Sebastian,Borgogno, Marco,Genna, Vito,Summa, Maria,Bertozzi, Sine Mandrup,Bertorelli, Rosalia,Armirotti, Andrea,Minarini, Anna,Sissi, Claudia,Osheroff, Neil,De Vivo, Marco
, p. 12873 - 12886 (2020/11/17)
We disclose a novel class of 6-Amino-Tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In contrast to topoII-Targeted drugs currently in clinical use, these compounds do not act as topo
Synthetic method of medical intermediate cycloalkanopyrimidinedione compound
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Paragraph 0032-0034, (2020/12/15)
The invention provides a synthetic method of a cycloalkanopyrimidinedione compound, and belongs to the technical field of organic synthesis. The method provided by the invention comprises the following steps of: taking a 2-methoxycarbonyl naphthenone comp