350684-49-0Relevant articles and documents
Memantine urea derivative as well as preparation method and application thereof
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, (2021/07/31)
The invention provides a memantine urea derivative as well as a preparation method and application thereof, and relates to the technical field of medicines. The memantine urea derivative provided by the invention has a typical urea structure as a primary
SMALL MOLECULE PROTEOLYSIS-TARGETING CHIMERAS AND METHODS OF USE THEREOF
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, (2020/12/30)
Novel small molecule proteolysis-targeting chimeras (PROTACs) are provided, along with methods for their use as Bruton's tyrosine kinase (BTK) degraders. The small molecule PROTACs described herein are useful in treating and/or preventing BTK-related diseases, such as cancer, neurodegenerative disorders, inflammatory diseases, and metabolic disorders. Also provided are methods for inducing BTK degradation in a cell using the compounds and compositions described herein. Exemplary compounds include: (I).
Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities
Su, Yue,Li, Ridong,Ning, Xianling,Lin, Zhiqiang,Zhao, Xuyang,Zhou, Juntuo,Liu, Jia,Jin, Yan,Yin, Yuxin
, p. 32 - 46 (2019/05/27)
A series of 2,4-diarylaminopyrimidine derivatives containing dithiocarbamate moiety were designed by molecular hybridization strategy and synthesized for screening as inhibitors of focal adhesion kinase (FAK). Most of these compounds exhibit significant a