3507-62-8Relevant articles and documents
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Gordon,J.J. et al.
, p. 819 - 825 (1975)
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Nitroalkanes and dimethyl maleate as source of 3-alkyl succinic anhydrides and (E)-3-alkylidene succinic anhydrides
Ballini, Roberto,Bosica, Giovanna,Fiorini, Dennis,Righi, Paolo
, p. 681 - 685 (2007/10/03)
Nitroalkanes react with dimethyl maleate giving a tandem Michael addition/elimination of nitrous acid. The obtained (E)-2-alkylidene dimethyl succinates are: (i) reduced to the corresponding 2-alkyl dimethyl succinates which after hydrolysis produce 1,4-dicarboxylic acids that are prone to convert into the corresponding 3-alkyl succinic anhydrides or (ii) hydrolysed to (E)-2-alkylidene-succinic acids that are easily cyclised to (E)-3-alkylidene succinic anhydrides.
Hydroxamic acids
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, (2008/06/13)
The invention provides a series of novel hydroxamic acids of the formula I which are useful as inhibitors of metalloproteases such as endopeptidases and wherein R1 is a hydrophobic group, R2 and R3 are each an amino acid residue, n is 1 or 2, and A is a group of the formula:-, -CHR4.CO.NH2, in which R4 is an amino acid residue. Also described are processes for the manufacture of the hydroxamic acids, pharmaceutically acceptable salts derived from the said acids and pharmaceutical compositions containing a said acid or salt.