350818-67-6

Basic information

• Product Name: RIMANTADINE-D4 HCL (ETHYL-D4)
• Synonyms: RIMANTADINE-D4 HCL (ETHYL-D4);RIMANTADINE-D4 HYDROCHLORIDE (ETHYL-D4);Rimantadine-D4 (ethyl-D4)HCl;1-ADAMANTYLETHYLAMINE HCl;Rimantadine-D4 (ethyl-D4)Cl;(1-(1-Adamantyl)ethylamineCl);RiMantadine-d4 HCl;1-(1-adamantyl)-1,2,2,2-tetradeuterioethanamine:hydrochloride
• CAS NO: 350818-67-6
• Molecular Formula: C12H18ClD4N
• Molecular Weight: 219.79
• Product Categories: Aromatic Halides (substituted)
• Mol File: 350818-67-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: RIMANTADINE-D4 HCL (ETHYL-D4)(CAS DataBase Reference)
• NIST Chemistry Reference: RIMANTADINE-D4 HCL (ETHYL-D4)(350818-67-6)
• EPA Substance Registry System: RIMANTADINE-D4 HCL (ETHYL-D4)(350818-67-6)

Safety Data

• Hazardous Substances Data: 350818-67-6(Hazardous Substances Data)

Usage

Description

Rimantadine-D4 HCl (Ethyl-D4) is an isotopically labeled version of Rimantadine Hydrochloride, which is an antiviral agent. It is primarily used in the field of pharmaceuticals and medical research for various applications due to its unique properties.

Uses

Used in Pharmaceutical Industry:
Rimantadine-D4 HCl (Ethyl-D4) is used as a research compound for the development and study of antiviral drugs. It aids in understanding the mechanisms of action, pharmacokinetics, and potential side effects of Rimantadine Hydrochloride, thereby contributing to the improvement of antiviral treatments.
Used in Medical Research:
In the field of medical research, Rimantadine-D4 HCl (Ethyl-D4) serves as a valuable tool for investigating the interactions between antiviral agents and viral proteins. This helps in the identification of new drug targets and the development of more effective antiviral therapies.
Used in Drug Metabolism Studies:
Rimantadine-D4 HCl (Ethyl-D4) is utilized in drug metabolism studies to analyze the metabolic pathways and enzyme interactions of Rimantadine Hydrochloride. This information is crucial for optimizing drug dosages, minimizing side effects, and enhancing the overall safety and efficacy of the treatment.
Used in Quality Control and Analytical Testing:
In the pharmaceutical quality control and analytical testing sectors, Rimantadine-D4 HCl (Ethyl-D4) is employed as a reference material for the accurate quantification and identification of Rimantadine Hydrochloride in various samples. This ensures the consistency, purity, and potency of the antiviral agent in the final drug product.

Upstream product

• 2094-72-6 1-Adamantanecarbonyl chloride 
• 828-51-3 1-Adamantanecarboxylic acid 
• 20137-98-8 Adamantyl-⁽¹⁾-carbaldehyd-oxim 

Relevant articles and documents

alpha-monodeuterated amine compound, deuterated medicine and preparation method of same

The invention relates to an alpha-monodeuterated amine compound and a reduction deuteration method of an oxime compound for preparing the alpha-monodeuterated amine compound. The method is characterized in that an oxime compound as shown in a general formula (1) reacts with a divalent lanthanide transition metal compound and a deuterium donor reagent in an organic solvent I to generate the alpha-monodeuterated amine compound as shown in a general formula (2), optionally, the compound shown in the general formula (2) is added into an organic acid and/or inorganic acid-organic solvent solution to obtain the ammonium salt shown in the general formula (2). The invention overcomes the defects that the preparation method of the alpha-monodeuterated amine compound in the prior art needs to adopt an expensive and highly toxic transition metal catalyst or an expensive and flammable metal deuteride and generates toxic by-products.

Stable isotope deuterium-labeled rimantadine hydrochloride and synthesis method thereof

The invention discloses stable isotope deuterium-labeled rimantadine hydrochloride and a synthesis method thereof. The synthesis method comprises the following steps: S1, reacting adamantane formyl chloride with deuterated methyl iodide to prepare deuterated adamantane methyl ketone; S2, enabling deuterated adamantane methyl ketone to react with hydroxylamine hydrochloride to prepare deuterated adamantane methyl ketoxime; and S3, reducing the deuterated adamantane methyl ketoxime by lithium aluminum deuteride, and adding hydrochloric acid for salifying to obtain the stable isotope deuterium-labeled rimantadine hydrochloride. The synthesis process is short in route, simple in process and mild in condition, the stable isotope deuterium cannot fall off, a product labeled by the stable isotopedeuterium at a specific position can be obtained, the product is easy to separate and purify and high in yield, the chemical purity and the stable isotope abundance of the obtained product both reach99% or above, and the requirements of serving as a standard reagent for quantitatively detecting the rimantadine hydrochloride are met; and the use value is high, and good economy is achieved.