35084-69-6

Basic information

• Product Name: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-, phenylmethyl ester
• Synonyms: N-(tert-Butoxycarbonyl)-L-alanyl-L-prolin-benzylester;Boc-L-alanyl-L-proline benzyl ester;BOC-Ala-Pro-OBZL;N-t-butoxycarbonyl-L-alanyl-L-proline benzyl ester
• CAS NO: 35084-69-6
• Molecular Formula: C20H28N2O5
• Molecular Weight: 376.453
• Mol File: 35084-69-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-, phenylmethyl ester(35084-69-6)
• EPA Substance Registry System: L-Proline, 1-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-, phenylmethyl ester(35084-69-6)

Safety Data

• Hazardous Substances Data: 35084-69-6(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 16357-59-8 N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline 
• 3392-05-0 Boc-Ala-O-N-hydroxysuccinimide 
• 100-51-6 benzyl alcohol 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 543-27-1 isobutyl chloroformate 

Relevant articles and documents

Glycopeptide derivatives for the preservation and protection of biological materials and microorganisms

The present invention relates to a compound of the following formula (I): in which at least one and only one group chosen among R5, R6 and R7 is a group of the following formula: The present invention relates also to uses

Levorotatory meptazinol prodrug as well as preparation method and purpose thereof

The invention provides a levorotatory meptazinol prodrug as well as a preparation method and a purpose thereof, wherein the levorotatory meptazinol prodrug is a compound as shown in a formula I or a stereoisomer, a geometrical isomer, a tautomer, oxynitride, a hydrate, a solvate, a metabolite or a pharmaceutically acceptable salt of the compound as shown in the formula I. The compound is low in hepatic first pass effect and high in bioavailability; a medicine which uses the compound as an active component can be used for treating a neurodegenerative disease or various kinds of acute and chronic pain, such as a wound, postoperative, obstetrical and cancer pain, hemicrania, neuropathic pain and the like.

N-bromosuccinimide oxidation of dipeptides and their amino acids: Synthesis, kinetics and mechanistic studies

Dipeptides (DP), namely valyl-glycine (Val-Gly), alanyl-proline (Ala-Pro), and valyl-proline (Val-Pro) were synthesized by classical solution phase methods and characterized. The kinetics of oxidation of amino acids (AA) and DP by N-bromosuccinimide (NBS) was studied in the presence of perchlorate ions in acidic medium at 28°C. The reaction was followed spectrophotometrically at λmax = 240 nm. The reactions follow identical kinetics, being first order each in [NBS], [AA], and [DP]. No effect on [H+], reduction product [succinimide], and ionic strength was observed. Effects of varying dielectric constant of the medium and addition of anions such as chloride and perchlorate were studied. Activation parameters have been computed. The oxidation products of the reaction were isolated and characterized. The proposed mechanism is consistent with the experimental results. An apparent correlation was noted between the rate of oxidation of AA and DP.