35094-46-3

Basic information

• Product Name: ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT
• Synonyms: SP-ATP-ALPHA-S SODIUM SALT;ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT;ADENOSINE 5''-(GAMMA-THIO)TRIPHOSPHATE;Adenosine-5'-O-(1-thiotriphosphate) lithium salt - 100 mM aqueous solution
• CAS NO: 35094-46-3
• Molecular Formula: C₁₀H₁₆N₅O₁₂P₃S
• Molecular Weight: 523.25
• Mol File: 35094-46-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 901.8±75.0 °C(Predicted)
• Appearance: /
• Density: 2.56±0.1 g/cm3(Predicted)
• PKA: 0.67±0.50(Predicted)
• CAS DataBase Reference: ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT(35094-46-3)
• EPA Substance Registry System: ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT(35094-46-3)

Safety Data

• Hazardous Substances Data: 35094-46-3(Hazardous Substances Data)

Usage

Description

ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT is a nucleoside triphosphate analogue that is structurally similar to ATP, with a key difference being the replacement of one of the oxygen atoms attached to the 3-phosphate group with a sulfur atom. This modification may result in altered biochemical properties and interactions with enzymes and cellular processes.

Uses

Used in Research Applications:
ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT is used as a research tool for studying the role of ATP in various biological processes. The sulfur substitution can affect the enzyme kinetics and interactions, providing insights into the mechanisms of ATP-dependent reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT may be used as a starting material for the development of novel therapeutic agents targeting ATP-dependent enzymes or pathways. Its unique properties could potentially be exploited to design drugs with improved selectivity and efficacy.
Used in Biochemical Assays:
ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT can be employed in the development of biochemical assays to measure the activity of ATP-dependent enzymes. The sulfur substitution may alter the enzyme's sensitivity to inhibition or activation, allowing for the identification of new regulatory mechanisms or potential drug targets.
Used in Drug Delivery Systems:
Similar to the use of gallotannin in drug delivery systems, ADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT could be incorporated into novel drug delivery platforms to improve the bioavailability and therapeutic outcomes of ATP-targeting drugs. The sulfur substitution may enhance the stability or cellular uptake of the compound, leading to more effective treatments.

Upstream product

• 58-64-0 adenosine 5'-diphosphate 

Downstream Products

• 58-64-0 adenosine 5'-diphosphate 
• 79049-97-1 uridine-5'-O-(3-thiotriphosphate) 

Relevant articles and documents

Practical Enzymatic Synthesis of Adenosine 5'-O-(3-Thiotriphosphate) (ATP-γ-S)

An enzymatic procedure for the synthesis of adenosine 5'-O-(3-thiotriphosphate) (ATP-γ-S) on a 50-mmol scale from dihydroxyacetone, sodium thiophosphate, ADP, and phosphoenol pyruvate is described.The synthesis uses polyacrylamide gel immobilized glycerokinase coupled to a pyruvate kinase catalyzed ATP cofactor regeneration system, and polyacrylamide gel immobilized triosephosphate isomerase, glyceraldehyde 3-phosphate dehydrogenase, and phosphoglycerate kinase coupled to a lactate dehydrogenase catalyzed NAD cofactor regeneration system.The ATP-γ-S is purified by adsorption on Dowex 1 and isolated as the sodium or barium salts in ca. 90 percent purity.