350982-89-7

Basic information

• Product Name: 2-(4-BROMOBENZYLIDENE)-4,6-DIMETHOXYBENZOFURAN-3-ONE
• Synonyms: 2-(4-BROMOBENZYLIDENE)-4,6-DIMETHOXYBENZOFURAN-3-ONE
• CAS NO: 350982-89-7
• Molecular Formula: C₁₇H₁₃BrO₄
• Molecular Weight: 361.19
• Mol File: 350982-89-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 529.5°C at 760 mmHg
• Flash Point: 274.1°C
• Appearance: /
• Density: 1.517g/cm³
• Vapor Pressure: 2.68E-11mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 2-(4-BROMOBENZYLIDENE)-4,6-DIMETHOXYBENZOFURAN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOBENZYLIDENE)-4,6-DIMETHOXYBENZOFURAN-3-ONE(350982-89-7)
• EPA Substance Registry System: 2-(4-BROMOBENZYLIDENE)-4,6-DIMETHOXYBENZOFURAN-3-ONE(350982-89-7)

Safety Data

• Hazardous Substances Data: 350982-89-7(Hazardous Substances Data)

Usage

Chemical group

Benzofuran

Molecular weight

374.19 g/mol

Usage

Organic synthesis, drug development, potential antitumor, antiviral, and antibacterial properties

Potential applications

Therapeutic agent, organic light-emitting diodes (OLEDs), and other optoelectronic devices.

InChI:InChI=1/C17H13BrO4/c1-20-12-8-13(21-2)16-14(9-12)22-15(17(16)19)7-10-3-5-11(18)6-4-10/h3-9H,1-2H3/b15-7+

Upstream product

• 4225-35-8 4,6-dimethoxycoumaranone 
• 1122-91-4 4-bromo-benzaldehyde 
• 108979-08-4 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(4-bromophenyl)prop-2-en-1-one 

Relevant articles and documents

Antischistosomal properties of aurone derivatives against juvenile and adult worms of Schistosoma mansoni

Schistosomiasis is a neglected disease caused by helminth flatworms of the genus Schistosoma, affecting over 240 million people in more than 70 countries. The treatment relies on a single drug, praziquantel, making urgent the discovery of new compounds. A

1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs

We report the synthesis and in vitro antiplasmodial activity of 35 compounds, designed as analogues of the naturally occurring aurones. Several of these analogues showed submicromolar antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum (FcB1-Columbia strain) cultured on human erythrocytes. Substitution of the intracyclic oxygen in aurones by a nitrogen atom and systematic variation of the substituent at the B-ring revealed promising leads showing good activity on the CQ-resistant strain. In particular, 4,6-dimethoxy-4′-ethylazaaurone 22 showed antiplasmodial potency without noticeable toxicity. The easy synthesis of this family of compounds and the relevant antiplasmodial activity are in favor of promising candidates for further development.

An efficient synthesis of 4,6 dimethoxyaurones

4,6-Dimethoxybenzofuran-3(2H)-one was synthesized in two steps starting from phloroglucinol and used as a useful starting block for the synthesis of aurones by condensation with benzaldehyde derivatives.