350997-68-1

Basic information

• Product Name: 3-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: ART-CHEM-BB B000243;AKOS B000243;3-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE;TIMTEC-BB SBB006908;3-(4-BROMOPHENYL)-1H-PYRAZOLE-4-CARBOXALDEHYDE;ALINDA 5805;VITAS-BB TBB002490;ZERENEX ZX009593
• CAS NO: 350997-68-1
• Molecular Formula: C₁₀H₇BrN₂O
• Molecular Weight: 251.08
• Mol File: 350997-68-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE(350997-68-1)
• EPA Substance Registry System: 3-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE(350997-68-1)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 350997-68-1(Hazardous Substances Data)

Usage

General Description

3-(4-Bromo-phenyl)-1H-pyrazole-4-carbaldehyde is a chemical compound with the molecular formula C10H7BrN2O. It is a pyrazole derivative and contains a bromo-phenyl group and a formyl group attached to the pyrazole ring. 3-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It has potential applications in the development of new drugs and in research related to bioactive compounds. The compound's structure and properties make it a useful building block for the creation of diverse molecular structures with biological activity.

Upstream product

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Downstream Products

• 618383-49-6 3-(4-bromo-phenyl)-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Synthesis and evaluation of antimicrobial and anticancer activities of 3-phenyl-1-phenylsulfonyl pyrazoles containing an aminoguanidine moiety

A series of 3-phenyl-1-phenylsulfonyl pyrazoles containing an aminoguanidine moiety was designed, synthesized, and evaluated for their antimicrobial and anticancer activities. The majority of the target compounds showed broad-spectrum antimicrobial activi

Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors

Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cationic channel, plays critical roles in insulin release, cytokine production, body temperature regulation and cell death as a reactive oxygen species (ROS) and temperature sensor. However, few TRPM2 inhibitors have been reported, especially TRP-subtype selective inhibitors, which hampers the investigation and validation of TRPM2 as a drug target. To discover novel TRPM2 inhibitors, 3D similarity-based virtual screening method was employed, by which 2,3-dihydroquinazolin-4(1H)-one derivative H1 was identified as a TRPM2 inhibitor. A series of novel 2,3-dihydroquinazolin-4(1H)-one derivatives were subsequently synthesized and characterized. Their inhibitory activities against the TRPM2 channel were evaluated by calcium imaging and electrophysiology approaches. Some of the compounds exhibited significant inhibitory activity, especially D9 which showed an IC50 of 3.7 μM against TRPM2 and did not affect the TRPM8 channel. The summarized structure-activity relationship (SAR) provides valuable insights for further development of specific TRPM2 targeted inhibitors.

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549?cell line with the half maximal inhibitory concentration (IC50) value of 1.48?μM, which was a more potent inhibitor than cisplatin (IC50?=?12.08?μM) and leading compound 2 (IC50?=?1.69?μM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a–d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased ΔTm values from 12.44 to 20.54?°C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549?cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.