351-12-2

Basic information

• Product Name: 3,3,3-trifluoro-N-phenylpropionamide
• Synonyms: 3,3,3-trifluoro-N-phenylpropionamide
• CAS NO: 351-12-2
• Molecular Weight: 203.164
• Mol File: 351-12-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,3,3-trifluoro-N-phenylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-trifluoro-N-phenylpropionamide(351-12-2)
• EPA Substance Registry System: 3,3,3-trifluoro-N-phenylpropionamide(351-12-2)

Safety Data

• Hazardous Substances Data: 351-12-2(Hazardous Substances Data)

Upstream product

• 41463-83-6 3,3,3-trifluoropropanoyl chloride 
• 62-53-3 aniline 
• 2516-99-6 3,3,3-Trifluoropropionic acid 

Downstream Products

• 103-84-4 Acetanilid 

Relevant articles and documents

Transition-Metal-Free Conversion of Trifluoropropanamides into Cyanoformamides through C-CF3 Bond Cleavage and Nitrogenation

A new transition-metal-free transformation of trifluoropropanamides into cyanoformamides through a sequence of C-CF3 bond cleavage and nitrogenation using tert-butyl nitrite as the nitrogen source is described. The method features direct detrifluoromethylation, broad substrate scopes, and excellent selectivity control, representing a new shortcut for constructing the nitrile group involving C-CF3 σ-bond cleavage.

Copper-Catalyzed Selective Defluorinative Sulfuration of Trifluoropropanamides Leading to α-Fluorothioacrylamides

A practical and efficient method for the synthesis of α-fluorothioacrylamide was developed from selective defluorinative sulfuration of trifluoropropanamides with disulfides. The N-chelation-assisted copper-catalyzed defluorination and sulfurization reactions feature excellent functional group tolerance and incorporation of both sulfur atoms of disulfides into acrylamides.