351-98-4

Basic information

• Product Name: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-
• CAS NO: 351-98-4
• Molecular Formula: C14H10F3N
• Molecular Weight: 249.235
• Mol File: 351-98-4.mol
• Article Data: 38

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(351-98-4)
• EPA Substance Registry System: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(351-98-4)

Safety Data

• Hazardous Substances Data: 351-98-4(Hazardous Substances Data)

Upstream product

• 26456-05-3 10-methylacridinium perchlorate 
• 5586-13-0 1-azido-4-(trifluoromethyl)benzene 
• 100-51-6 benzyl alcohol 
• 402-54-0 p-nitrobenzotrifluoride 
• 100-52-7 benzaldehyde 
• 23056-94-2 2-methyl-1-hexen-3-yne 
• 455-14-1 4-trifluoromethylphenylamine 
• 538-51-2 benzylidene phenylamine 

Downstream Products

• 1063600-14-5 6-trifluoromethyl-4-(p-methoxyphenyl)-2-phenylquinoline 
• 945033-50-1 6-trifluoromethyl-4-(triisopropylsilyl)methyl-2-phenylquinoline 
• 405-81-2 N-benzyl-4-(trifluoromethyl)aniline 
• 1131726-84-5 3,3-dichloro-4-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one 
• 2994-80-1 3-methyl-N-(4-trifluoromethylphenyl)butyramide 
• 1621980-91-3 C₃₀H₃₈F₃N 

Relevant articles and documents

Rhodium(III)-amine dual catalysis for the oxidative coupling of aldehydes by directed C-H activation: Synthesis of phthalides

A novel oxidative coupling of aldehydes to form C3-substituted phthalides facilitated by co-operative dual catalysis of a Rh(III) complex and an aryl amine is reported. The reaction involves a cascade ortho C-H activation-insertion-annulation sequence. This methodology is efficient and applicable for the homo- and heterocoupling of various functionalized aldehydes generating the corresponding phthalides in moderate to high yields.

Metal-free regioselective C-H amination for the synthesis of pyrazole-containing 2H-indazoles

A general and practical regioselective approach for the C-H amination of 2H-indazoles under transition-metal-free conditions was developed. A series of substrates were tested showing eminent functional group tolerance and affording the C-N functionalization products in good to excellent yields. Mechanism studies revealed that a radical process was involved in this transformation.

Direct synthesis of imines from nitro compounds and biomass-derived carbonyl compounds over nitrogen-doped carbon material supported Ni nanoparticles

The selective synthesis of imines from biomass-derived chemicals over heterogeneous non-noble metal catalysts is of great importance for organic transformation. Herein, non-noble heterogeneous nitrogen-doped carbon supported Ni catalysts (abbreviated as Ni/CN-MgO-T, whereTrepresents the pyrolysis temperature) have been facilely prepared from the simple pyrolysis of Ni precursors and biomass, and Ni/CN-MgO-600 with the smallest size of Ni nanoparticles demonstrated the highest catalytic activity. The reductive coupling of nitroarenes and carbonyl compounds could be performed under mild conditions (80 °C, and 10 bar H2), affording structurally-diverse imines with high to excellent yields (84.2-98.1%). Thanks to the mild reaction conditions, the developed method showed good tolerance to other functional groups such as nitriles, halogen and vinyl groups.