35114-04-6

Basic information

• Product Name: 3,5-Dichloro-N,N-dimethylaniline
• Synonyms: 3,5-Dichloro-N,N-dimethylaniline
• CAS NO: 35114-04-6
• Molecular Formula: C₈H₉Cl₂N
• Molecular Weight: 190.07
• Mol File: 35114-04-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 273.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• PKA: 2.77±0.19(Predicted)
• CAS DataBase Reference: 3,5-Dichloro-N,N-dimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-N,N-dimethylaniline(35114-04-6)
• EPA Substance Registry System: 3,5-Dichloro-N,N-dimethylaniline(35114-04-6)

Safety Data

• Hazardous Substances Data: 35114-04-6(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 626-43-7 3,5-Dichloroaniline 
• 108-70-3 1,3,5-trichlorobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 67-56-1 methanol 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 

Downstream Products

• 33739-96-7 3,5-Dichlor-N,N-dimethyl-4-nitro-anilin 
• 97203-14-0 N,N-Dimethyl-4-nitro-2,3,5,6-tetrachlor-anilin 
• 73164-28-0 2,6-Dichloro-N',N'-dimethyl-benzene-1,4-diamine 
• 112449-32-8 N⁴,N⁴-Dimethyl-2,3,6-trichlor-p-phenylendiamin 
• 112449-31-7 N⁴,N⁴-Dimethyl-2,3,5,6-tetrachlor-p-phenylendiamin 
• 97203-12-8 N,N-Dimethyl-4-nitro-2,3,5-trichlor-anilin 
• 55875-44-0 2,6-dichloro-4-(dimethylamino)benzaldehyde 
• 1295650-73-5 3,5-dichlorophenyltrimethylammonium methyl sulfate 
• 1427461-90-2 C₁₂H₁₃Cl₂N₃O 

Relevant articles and documents

Aminomethylation of Aryl Bromides by Nickel-Catalyzed Electrochemical Redox Neutral Cross Coupling

We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use of anode and cathode processes, free of a terminal oxidant, a sacrificial anode, a metal reductant, and a prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents and aromatic heterocycles. This redox neutral cross coupling provides a more environmentally friendly and synthetic practical protocol for forging C(sp2)–C(sp3) bonds.

Copper-free sonogashira cross-coupling for functionalization of alkyne-encoded proteins in aqueous medium and in bacterial cells

Bioorthogonal reactions suitable for functionalization of genetically or metabolically encoded alkynes, for example, copper-catalyzed azide-alkyne cycloaddition reaction ("click chemistry"), have provided chemical tools to study biomolecular dynamics and function in living systems. Despite its prominence in organic synthesis, copper-free Sonogashira cross-coupling reaction suitable for biological applications has not been reported. In this work, we report the discovery of a robust aminopyrimidine-palladium(II) complex for copper-free Sonogashira cross-coupling that enables selective functionalization of a homopropargylglycine (HPG)-encoded ubiquitin protein in aqueous medium. A wide range of aromatic groups including fluorophores and fluorinated aromatic compounds can be readily introduced into the HPG-containing ubiquitin under mild conditions with good to excellent yields. The suitability of this reaction for functionalization of HPG-encoded ubiquitin in Escherichia coli was also demonstrated. The high efficiency of this new catalytic system should greatly enhance the utility of Sonogashira cross-coupling in bioorthogonal chemistry.

Benzylideneamino- and phenylacetylguanidines and their pharmaceutical uses

Compounds of formula (I): STR1 or a salt or acyl derivative thereof; wherein Y is either --CH=N or STR2 R1 is hydroxy, halogen, (C1-4) alkyl, or (C1-4)alkoxy, R2 is a nitrogen-containing, basic substituent, R3 is hydrogen, hydroxy, halogen, (C1-4) alkyl, (C1-4) alkoxy or a nitrogen-containing, basic substituent, and R4 is hydrogen or hydroxy, are useful in treating diarrhoea and scours.