3512-13-8

Basic information

• Product Name: 2,3,4,6-TETRAFLUOROPYRIDINE
• Synonyms: 2,3,4,6-TETRAFLUOROPYRIDINE;2,3,4,6-TETRAFLUOROPYRIDINE, 98+%;2,3,4,6-tetrafluoropyridine(SALTDATA: FREE);T239;Pyridine,2,3,4,6-tetrafluoro-
• CAS NO: 3512-13-8
• Molecular Formula: C₅HF₄N
• Molecular Weight: 151.06
• EINECS: -0
• Mol File: 3512-13-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 88-90°C
• Flash Point: 88-90°C
• Appearance: /
• Density: 1.518g/cm³
• Vapor Pressure: 23.4mmHg at 25°C
• Refractive Index: 1.399
• PKA: -9.66±0.18(Predicted)
• BRN: 1368002
• CAS DataBase Reference: 2,3,4,6-TETRAFLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,6-TETRAFLUOROPYRIDINE(3512-13-8)
• EPA Substance Registry System: 2,3,4,6-TETRAFLUOROPYRIDINE(3512-13-8)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: UN2924
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 3512-13-8(Hazardous Substances Data)

Usage

General Description

2,3,4,6-tetrafluoropyridine is a chemical compound with the molecular formula C5H2F4N. It is a colorless liquid with a faint aromatic odor, and it is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. Its chemical properties make it useful in the production of insecticides, herbicides, and other agricultural chemicals. It is also used in the manufacture of dyes and pigments, as well as in the production of specialty chemicals and organic synthesis. Additionally, 2,3,4,6-tetrafluoropyridine has potential applications in the field of electronics, such as in the production of photoresist materials. However, it is important to handle this chemical with care, as it can be toxic and may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C5HF4N/c6-2-1-3(7)10-5(9)4(2)8/h1H

Upstream product

• 110-86-1 pyridine 
• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 1333-74-0 hydrogen 
• 700-16-3 Pentafluoropyridine 

Downstream Products

• 858860-02-3 2,3,6-trifluoro-4-methoxypyridine 
• 74199-51-2 2,4,5,6-tetrafluoro-3-hydroxypyridine 
• 63489-59-8 3,4,6-trifluoro-pyridin-2-ylamine 
• 63489-55-4 4-Amino-2,3,6-trifluoropyridine 
• 3512-15-0 2,4,5,6-Tetrafluoronicotinic acid 
• 24306-75-0 2,4,5,6-Tetrafluoronicotinaldehyde 
• 259675-74-6 4-Aminotrifluoronicotinic acid 
• 259675-77-9 2,3,4,6-tetrafluoro-5-(trimethylsilyl)pyridine 
• 1081978-32-6 2,3,6-trifluoro-N-phenylpyridin-2-amine 
• 1081978-36-0 3,4,6-trifluoro-N-phenylpyridin-2-amine 
• 1210835-59-8 3-chloro-5-(2,3,6-trifluoropyridin-4-yloxy)benzonitrile 
• 29636-84-8 2,3,4,6-tetrafluoro-5-phenylpyridine 

Relevant articles and documents

Photocatalytic hydrodefluorination: Facile access to partially fluorinated aromatics

Polyfluorinated aromatics are essential to materials science as well as the pharmaceutical and agrochemical industries and yet are often difficult to access. This Communication describes a photocatalytic hydrodefluorination approach which begins with easily accessible perfluoroarenes and selectively reduces the C-F bonds. The method allows facile access to a number of partially fluorinated arenes and takes place with unprecedented catalytic activity using a safe and inexpensive amine as the reductant.

Preparation and reactions of 2,3,4,6-tetrafluoropyridine and its derivatives

A reliable route to 2,3,4,6-tetrafluoropyridine has been established starting from the readily available 3,5-dichlorotrifluoropyridine by halogen exchange under controlled conditions to give 3-chlorotetrafluoropyridine and its subsequent hydrodechlorination using hydrogen over palladium on alumina at 250-270°C. The formation and reactions of the 3-lithio derivative have been studied with the aim of obtaining 3,4-disubstituted trifluoropyridines. Routes to such materials have been developed and their conversion to deazapurine derivatives as potential substrates for the generation of anti-sense nucleosides are reported.