35121-60-9

Basic information

• Product Name: 10-methoxy-6-methylergoline-8beta-methanol
• Synonyms: 10-methoxy-6-methylergoline-8beta-methanol;10-methoxy-9,10-dihydrolysergol;10-Methoxy-6-methylergoline-8β-methanol;[(6aR,9R,10aS)-10a-methoxy-7-methyl-4,6,6a,8,9,10-hexahydroindolo[4,3-fg]quinoline-9-yl]methanol
• CAS NO: 35121-60-9
• Molecular Formula: C₁₇H₂₂N₂O₂
• Molecular Weight: 286.36878
• EINECS: 252-385-1
• Product Categories: Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 35121-60-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 456.8°Cat760mmHg
• Flash Point: 230.1°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.002Pa at 20℃
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
• PKA: 14.87±0.10(Predicted)
• Water Solubility: 440mg/L at 20℃
• CAS DataBase Reference: 10-methoxy-6-methylergoline-8beta-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 10-methoxy-6-methylergoline-8beta-methanol(35121-60-9)
• EPA Substance Registry System: 10-methoxy-6-methylergoline-8beta-methanol(35121-60-9)

Safety Data

• Hazardous Substances Data: 35121-60-9(Hazardous Substances Data)

Usage

Description

10-methoxy-6-methylergoline-8beta-methanol is a chemical compound derived from the ergoline family, characterized by its light brown solid appearance. It is a derivative of Lysergol and Dehydrolysergol-I, which are known to act as partial agonists and antagonists at various receptors, including 5-HT2A, 5-HT2C, 5-HT1B, and α1-andrenergic receptors.

Uses

Used in Pharmaceutical Industry:
10-methoxy-6-methylergoline-8beta-methanol is used as a pharmaceutical compound for its receptor modulating properties. It serves as a potential candidate for the development of drugs targeting various neurological and psychiatric disorders due to its interaction with serotonin and adrenergic receptors.
Used in Research and Development:
In the field of research and development, 10-methoxy-6-methylergoline-8beta-methanol is utilized as a chemical intermediate for the synthesis of novel compounds with potential therapeutic applications. Its unique receptor binding profile makes it a valuable tool in understanding the mechanisms of action of various psychoactive substances and developing new treatments for related conditions.
Used in Chemical Synthesis:
10-methoxy-6-methylergoline-8beta-methanol is also used as a key building block in the synthesis of other ergoline-derived compounds. Its structural features make it a versatile starting material for the creation of new molecules with diverse biological activities, contributing to the advancement of chemical science and drug discovery.

Flammability and Explosibility

Notclassified

Upstream product

• 82-58-6 D-lysergic acid 
• 67-56-1 methanol 
• 602-85-7 lysergol 

Downstream Products

• 35155-28-3 1-Methyl-10alpha-methoxy-9,10-dihydrolysergol 

Relevant articles and documents

Improved preparation method of nicergoline (by machine translation)

Compared the prior art,bromonicotinoyl chloride intermediate, is prepared-methoxyphenylglycinol :(1) by a reaction with an organic amine as, an acid-binding agent, to produce 10α -(2) methyl - 101010101010101010and X3B1,methoxyphenylglycinol, in a solvent, 10α - The final yield of the product can reach or above product to be 1 - suitable for large-scale ;(3) production, The, method 5 - comprises the following 5 - steps 5 - carrying out a methylation reaction 1 - with an organic, amine, as an organic amine as an acid,binding compound, in a solvent in a solvent and an inorganic base by an organic amine as an acid-binding agent in, an amide type non-protonic solvent to prepare 50% the . nylmyralyl chloride 99%, midst with an organic amine as an organic amine as an acid-binding agent. (by machine translation)

New preparation method of 10alpha-methoxy-9,10-MMDL

The invention discloses a preparation method of 10alpha-methoxy-9,10-MMDL, which is high in product yield, good in product quality, simple in process and suitable for industrial production. The preparation method of 10alpha-methoxy-9,10-MMDL includes the following steps that S1, an intermediate is prepared, wherein lysergic acid and methyl alcohol are subjected to a methoxylation reaction, and after purification, the intermediate 10alpha-methoxy-9,10-dihydrolysergic acid methyl ester is obtained; S2, the intermediate 10alpha-methoxy-9,10-dihydrolysergic acid methyl ester reacts with a reductant, and after purification, 10alpha-methoxy-9,10-MMDL is obtained. By means of the preparation method of 10alpha-methoxy-9,10-MMDL, reaction conditions are mild, operation is easy, the product qualityis good, the product yield is high, the total yield reaches 75% or above, and industrial application and promotion are facilitated.

Neue nootrop wirksame Ergoline

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