35168-62-8Relevant articles and documents
Chiral dithia[n]paracyclophanes - Synthesis, crystal structure, and chiroptical properties
Pischel, Ivo,Nieger, Martin,Archut, Andreas,Voegtle, Fritz
, p. 10043 - 10052 (1996)
The synthesis of the shortly bridged dithia[n]paracyclophanes (n = 7, 8) 1-5 was achieved by the cesium-assisted high-dilution cyclization for the first time. A chiral molecular structure is induced by the pattern of the two methyl substituents. A structure with C1 symmetry for the dithia[7]paracyclophane 1 is proven by X-ray structure analysis and by low-temperature NMR experiments. The benzene ring is strongly deformed to a boat-shaped conformation. Enantiomeric separation of the cyclophanes 2-5 and the circular dichrograms of the enantiomers are discussed.
Two coordination polymers with the ligand salicylamide: Synthesis, crystal structure and luminescent properties
Song, Xueqin,Xiao, Zhourong,Zhao, Mengmeng,Qian, Wenhui
, p. 1769 - 1775 (2014)
The semirigid exo-bidentate ligand 1, 4-bis{[(2′-picolylaminoformyl) phenoxyl]methyl}-2, 5-bismethylbenzene (L) was designed, synthesized, and used as building blocks for constructing luminescent lanthanide polymers. Two new lanthanide coordination polymers were characterized by elemental analysis, X-ray diffraction analysis, and IR spectroscopy. The coordination polymers exhibit the metal-to-ligand molar ratio of 1:1 and the semirigid exo-bidentate ligand bridges lanthanide nitrates forming a zigzag chain, which further interconnected to three dimensional supramolecular structure in aid of cooperative C-H...O hydrogen bonds. The luminescence properties of the europium(III) complex are discussed in detail. Copyright
Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer
Banerjee, Kaustav,Padmavathi, Ganesan,Bhattacherjee, Debojit,Saha, Suchismita,Kunnumakkara, Ajaikumar B.,Bhabak, Krishna P.
supporting information, p. 8769 - 8782 (2018/11/30)
The pharmacological importance, particularly the anti-cancer and chemopreventive potentials, of organochalcogen compounds has attracted wide research attention recently. Herein we describe the synthesis of a series of organochalcogenocyanates that have one or more selenocyanate or thiocyanate units in a single molecule. The anti-proliferative activity of these organochalcogenocyanates in different breast cancer cells shows that selenocyanates exhibit much higher anti-proliferative activities than thiocyanates in general. Our study reveals that the activity of benzyl selenocyanate (1, BSC) could be significantly enhanced by 4-nitro substitution (12), which was more selective towards triple-negative breast cancer cells (MDA-MB-231) over other ER+ breast cancer cells (MCF-7 and T-47D). Furthermore, to the best of our knowledge, this is the first report on the synthesis of compounds having more than two selenocyanate units with promising anti-proliferative activities. Our studies further indicate that the apoptotic activities of selenocyanates are associated with modulation of cellular morphology and cell cycle arrest at S-phase. Selenocyanates also inhibited cellular migration and exhibited weak antioxidant activities. An effective binding interaction of compound 12 with serum albumin indicates its feasible transport in the bloodstream for its enhanced anti-cancer properties. Mechanistic studies by western blot analysis demonstrate that benzylic selenocyanates exhibit anti-proliferative activities by modulating key cellular proteins such as Survivin, Bcl-2 and COX-2; this was further supported by molecular docking studies. The results of this study would be helpful in designing suitable chemotherapeutic and chemopreventive drugs in the future.
NOVEL LIQUID CRYSTALLINE COMPOUND, LIQUID CRYSTAL COMPOSITION, OPTICAL ELEMENT AND OPTICAL DISPLAY DEVICE
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Paragraph 0096, (2018/10/16)
PROBLEM TO BE SOLVED: To provide a novel liquid crystalline compound that is low in dielectric anisotropy, has responsiveness, and changes its birefringence by application of voltage. SOLUTION: The present invention provides a compound represented by formula (1) (In the formula (1), R1, R2 and R3 independently represent a hydrogen atom or C1-C10 alkyl, in the alkyl, at least one -CH2- may be substituted by -O-, -S-, -CO-, or -SiH2-, and at least one -(CH2)2- may be substituted by -CH=CH-or -C≡C-. n is an integer of 0-4. m is an integer of 1 or 2. Z1 and Z2 are -CH=CH-). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT