35173-76-3

Basic information

• Product Name: Benzenamine, 4-(di-1H-indol-3-ylmethyl)-N,N-dimethyl-
• CAS NO: 35173-76-3
• Molecular Formula: C25H23N3
• Molecular Weight: 365.478
• Mol File: 35173-76-3.mol
• Article Data: 55

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-(di-1H-indol-3-ylmethyl)-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-(di-1H-indol-3-ylmethyl)-N,N-dimethyl-(35173-76-3)
• EPA Substance Registry System: Benzenamine, 4-(di-1H-indol-3-ylmethyl)-N,N-dimethyl-(35173-76-3)

Safety Data

• Hazardous Substances Data: 35173-76-3(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 889-37-2 N,N-dimethyl-4-((phenylimino)methyl)aniline 
• 2829-28-9 4-dimethylamino-benzaldehyde phenylhydrazone 
• 121-69-7 N,N-dimethyl-aniline 
• 1703-46-4 N,N-dimethyl-4-hydroxymethylaniline 
• 67-56-1 methanol 
• 7664-93-9 sulfuric acid 

Downstream Products

• 1426131-55-6 C₄₈H₈₀O₄₀*C₂₅H₂₃N₃ 
• 1426131-53-4 C₃₆H₆₀O₃₀*C₂₅H₂₃N₃ 
• 1426131-54-5 C₄₂H₇₀O₃₅*C₂₅H₂₃N₃ 

Relevant articles and documents

Facile synthesis of bis(indolyl)methanes using iron(III) phosphate

A new, convenient and high yielding procedure for the preparation of bis(indolyl)methanes in glycerol by the electrophilic substitution reaction of indole with aldehydes in the presence of catalytic amount of FePO4 (5.0 mol %) as a highly stabl

Preparation of G-CuO NPs and G-ZnO NPs with mallow leaves, investigation of their antibacterial behavior and synthesis of bis(indolyl)methane compounds under solvent-free microwave assisted dry milling conditions using G-CuO NPs as a catalyst

In this study, biogenic copper and zinc oxide nanoparticles (G-ZnONPs and G-CuONPs) were synthesized by the green synthesis method using Malva parviflora L. (Millow) leaf extract and the obtained nanoparticles were characterized in detail with UV-Vis, FTIR, SEM, XRD. The antibacterial properties of the synthesized nanoparticles on gram-positive and gram-negative bacteria were investigated and it was found that the nanoparticles had high antimicrobial activity in the results of the experiments. With the obtained G-CuONPs, the synthesis of bis(indolyl)methanes with the "green" one-pot synthesis using microwave was achieved quickly and with high efficiency, and the thermal behavior of the obtained products was investigated.

Bis-indolylation of aldehydes and ketones using silica-supported FeCl3: Molecular docking studies of bisindoles by targeting SARS-CoV-2 main protease binding sites

We report herein an operationally simple, efficient and versatile procedure for the synthesis of bis-indolylmethanes via the reaction of indoles with aldehydes or ketones in the presence of silica-supported ferric chloride under grindstone conditions. The prepared supported catalyst was characterized by SEM and EDX spectroscopy. The present protocol has several advantages such as shorter reaction time, high yield, avoidance of using harmful organic solvents during the reaction and tolerance of a wide range of functional groups. Molecular docking studies targeted toward the binding site of SARS-CoV-2 main protease (3CLpro or Mpro) enzymes were investigated with the synthesized bis-indoles. Our study revealed that some of the synthesized compounds have potentiality to inhibit the SARS-CoV-2 Mpro enzyme by interacting with key amino acid residues of the active sites via hydrophobic as well as hydrogen bonding interactions.