351858-24-7

Basic information

• Product Name: C₁₅H₁₀N₄S
• Synonyms: C₁₅H₁₀N₄S
• CAS NO: 351858-24-7
• Molecular Weight: 278.337
• Mol File: 351858-24-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₀N₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₀N₄S(351858-24-7)
• EPA Substance Registry System: C₁₅H₁₀N₄S(351858-24-7)

Safety Data

• Hazardous Substances Data: 351858-24-7(Hazardous Substances Data)

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 1416371-24-8 (E)-N'-(2-cyanothieno[2,3-b]pyridin-3-yl)-N,N-dimethylformimidamide 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d] pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors

A useful and rapid access to libraries of N-arylbenzo[b]thieno[3,2-d] pyrimidin-4-amines and their pyrido and pyrazino analogues was designed and optimized for the first time via microwave-accelerated condensation and Dimroth rearrangement of the starting anilines with N′-(2-cyanoaryl)-N,N- dimethylformimidamides obtained by reaction of thiophene precursors with dimethylformamide dimethylacetal. The inhibitory potency of the final products against five protein kinases (CDK5/p25, CK1δ/ε, GSK3α/β, DYRK1A and CLK1) was estimated. N-arylpyrido[3′,2′:4,5]thieno[3,2-d] pyrimidin-4-amine series of compounds (4a-j) turned out to be particularly promising for the development of new pharmacological inhibitors of CK1 and CLK1 kinases.