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352-11-4

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352-11-4 Usage

Description

Alpha-Chloro-p-fluorotoluene, also known as 4-(chloromethyl)fluorobenzene, is an organic compound that belongs to the class of aromatic halides. It is a clear colorless to slightly yellow liquid at room temperature and is characterized by its distinct chemical structure, which features a chlorine atom and a fluorine atom attached to a toluene molecule. This unique structure endows it with specific chemical properties that make it a valuable intermediate in the synthesis of various compounds.

Uses

Used in Pharmaceutical Industry:
Alpha-Chloro-p-fluorotoluene is used as a chemical intermediate for the synthesis of various pharmaceutical products. Its unique structure allows for the creation of a wide range of medicinal compounds with diverse therapeutic applications, including antibiotics, anti-inflammatory drugs, and central nervous system agents. The presence of the chlorine and fluorine atoms in its molecular structure facilitates various chemical reactions, making it an essential building block in the development of new drugs.
Used in Agricultural Industry:
In addition to its applications in the pharmaceutical industry, alpha-Chloro-p-fluorotoluene is also utilized as a chemical intermediate in the synthesis of agricultural goods. It plays a crucial role in the production of various agrochemicals, such as pesticides, herbicides, and fungicides, which are essential for maintaining crop health and increasing agricultural productivity. The versatility of alpha-Chloro-p-fluorotoluene in chemical reactions enables the development of novel and effective agrochemicals to combat pests and diseases in the agricultural sector.
Used in Chemical Research:
Due to its unique chemical properties and reactivity, alpha-Chloro-p-fluorotoluene is also employed in various research applications. It serves as a valuable starting material for the synthesis of complex organic molecules and is used in the development of new synthetic methods and reaction pathways. Researchers in the field of organic chemistry often utilize alpha-Chloro-p-fluorotoluene to study the effects of different functional groups on the reactivity and stability of aromatic compounds, contributing to the advancement of chemical knowledge and the discovery of new compounds with potential applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 352-11-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 352-11:
(5*3)+(4*5)+(3*2)+(2*1)+(1*1)=44
44 % 10 = 4
So 352-11-4 is a valid CAS Registry Number.
InChI:InChI:1S/C7H6ClF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2

352-11-4 Well-known Company Product Price

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  • Alfa Aesar

  • (A14686)  4-Fluorobenzyl chloride, 99%   

  • 352-11-4

  • 25g

  • 383.0CNY

  • Detail
  • Alfa Aesar

  • (A14686)  4-Fluorobenzyl chloride, 99%   

  • 352-11-4

  • 100g

  • 1192.0CNY

  • Detail
  • Alfa Aesar

  • (A14686)  4-Fluorobenzyl chloride, 99%   

  • 352-11-4

  • 500g

  • 5220.0CNY

  • Detail

352-11-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(chloromethyl)-4-fluorobenzene

1.2 Other means of identification

Product number -
Other names 1-Chloromethyl-4-fluoro-benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:352-11-4 SDS

352-11-4Relevant articles and documents

p-Fluorobenzaldehyde and p-fluorobenzoic acid by oxidation of p-fluorobenzyl derivatives

Conte,Napoli,Gambaretto,Carlini,Bonini

, p. 19 - 23 (1998)

Experiments on the oxidation reactions of p-fluorobenzyl alcohol and chloride were carried out. Several oxidizing agents (manganese dioxide, 30% hydrogen peroxide and hypochlorite solutions at different concentrations) were used, and a mixture of p-fluorobenzaldehyde and p-fluorobenzoic acid in different proportions was obtained. In the case of p-fluorobenzyl chloride, some p-fluorobenzyl alcohol was also found in the reaction mixture. The experimental conditions required to obtain an increase in the yield of the aldehyde or acid were also studied.

One-Pot Deoxygenation and Substitution of Alcohols Mediated by Sulfuryl Fluoride

Epifanov, Maxim,Mo, Jia Yi,Dubois, Rudy,Yu, Hao,Sammis, Glenn M.

, p. 3768 - 3777 (2021/03/01)

Sulfuryl fluoride is a valuable reagent for the one-pot activation and derivatization of aliphatic alcohols, but the highly reactive alkyl fluorosulfate intermediates limit both the types of reactions that can be accessed as well as the scope. Herein, we report the SO2F2-mediated alcohol substitution and deoxygenation method that relies on the conversion of fluorosulfates to alkyl halide intermediates. This strategy allows the expansion of SO2F2-mediated one-pot processes to include radical reactions, where the alkyl halides can also be exploited in the one-pot deoxygenation of primary alcohols under mild conditions (52-95% yield). This strategy can also enhance the scope of substitutions to nucleophiles that are previously incompatible with one-pot SO2F2-mediated alcohol activation and enables substitution of primary and secondary alcohols in 54-95% yield. Chiral secondary alcohols undergo a highly stereospecific (90-98% ee) double nucleophilic displacement with an overall retention of configuration.

N -Hydroxyphthalimide/benzoquinone-catalyzed chlorination of hydrocarbon C-H bond using N -chlorosuccinimide

Li, Zi-Hao,Fiser, Béla,Jiang, Biao-Lin,Li, Jian-Wei,Xu, Bao-Hua,Zhang, Suo-Jiang

supporting information, p. 3403 - 3408 (2019/04/01)

The direct chlorination of C-H bonds has received considerable attention in recent years. In this work, a metal-free protocol for hydrocarbon C-H bond chlorination with commercially available N-chlorosuccinimide (NCS) catalyzed by N-hydroxyphthalimide (NHPI) with 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) functioning as an external radical initiator is presented. Aliphatic and benzylic substituents and also heteroaromatic ones were found to be well tolerated. Both the experiments and theoretical analysis indicate that the reaction goes through a process wherein NHPI functions as a catalyst rather than as an initiator. On the other hand, the hydrogen abstraction of the C-H bond conducted by a PINO species rather than the highly reactive N-centered radicals rationalizes the high chemoselectivity of the monochlorination obtained by this protocol as the latter is reactive towards the C(sp3)-H bonds of the monochlorides. The present results could hold promise for further development of a nitroxy-radical system for the highly selective functionalization of the aliphatic and benzylic hydrocarbon C-H.

α-Diimine-Niobium Complex-Catalyzed Deoxychlorination of Benzyl Ethers with Silicon Tetrachloride

Parker, Bernard F.,Hosoya, Hiromu,Arnold, John,Tsurugi, Hayato,Mashima, Kazushi

supporting information, p. 12825 - 12831 (2019/10/19)

α-Diimine niobium complexes serve as catalysts for deoxygenation of benzyl ethers by silicon tetrachloride (SiCl4) to cleanly give two equivalents of the corresponding benzyl chlorides, where SiCl4 has the dual function of oxygen scavenger and chloride source with the formation of a silyl ether or silica as the only byproduct. The reaction mechanism has two successive trans-etherification steps that are mediated by the niobium catalyst, first forming one equivalent of benzyl chloride along with the corresponding silyl ether intermediate that undergoes the same reaction pathway to give the second equivalent of benzyl chloride and silyl ether.

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