352018-92-9

Basic information

• Product Name: 5-IODO-2-PHENOXYPYRIDINE
• Synonyms: 5-IODO-2-PHENOXYPYRIDINE
• CAS NO: 352018-92-9
• Molecular Formula: C₁₁H₈INO
• Molecular Weight: 297.09
• Mol File: 352018-92-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 339.8 °C at 760 mmHg
• Flash Point: 159.3 °C
• Appearance: /
• Density: 1.694 g/cm³
• Vapor Pressure: 0.000177mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-IODO-2-PHENOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-2-PHENOXYPYRIDINE(352018-92-9)
• EPA Substance Registry System: 5-IODO-2-PHENOXYPYRIDINE(352018-92-9)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S36/37:Wear suitable protective clothing and gloves.
• Hazardous Substances Data: 352018-92-9(Hazardous Substances Data)

Usage

General Description

5-IODO-2-PHENOXYPYRIDINE is a chemical compound with the molecular formula C11H8IN2O. It belongs to the pyridine family and is classified as a halogenated aromatic compound. This chemical is characterized by the presence of an iodo and a phenoxy group attached to a pyridine ring. It is commonly used in the pharmaceutical industry as a building block in the synthesis of various pharmaceutical products. Furthermore, it is also utilized in research and development for the creation of new chemical compounds for medicinal purposes. Additionally, 5-IODO-2-PHENOXYPYRIDINE is known for its potential as an active ingredient in the production of agrochemicals for crop protection and pest control.

InChI:InChI=1/C11H8INO/c12-9-6-7-11(13-8-9)14-10-4-2-1-3-5-10/h1-8H

Upstream product

• 25194-67-6 6-phenoxy-pyridin-3-ylamine 
• 4487-59-6 2-bromo-5-nitropyridine 
• 28222-02-8 3-nitro-6-phenoxypyridine 
• 108-95-2 phenol 
• 73290-22-9 2-bromo-5-iodo-pyridine 

Downstream Products

• 1024592-19-5 C₂₀H₁₅NO₂ 
• 1024592-20-8 C₂₁H₁₇NO₃ 
• 1258870-91-5 2-phenoxy-5-phenylsulfanylpyridine 
• 1353767-43-7 (S)-N-{1-[4-(6'-phenoxy-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-4-yl)phenyl]ethyl}acetamide 

Relevant articles and documents

Aminoarenethiolato-copper(I) as (pre-)catalyst for the synthesis of diaryl ethers from aryl bromides and sequential C-O/C-S and C-N/C-S cross coupling reactions

A small library of 2-aminoarenethiolato-copper(I) (CuSAr) complexes was tested as (pre-)catalysts in the arylation reaction of phenols with aryl bromides. These copper(I) (pre-)catalysts are thermally stable, soluble in common organic solvents, and allow reactions of 6 h at 160 °C with low catalyst loadings of 2.5 mol %. Among the (pre-)catalysts screened, 2-[(dimethylamino)methyl]benzenethiolato-copper(I) (1c) led to the best results and provided good to excellent yields of various substituted diaryl ethers. Mechanistic studies showed that at early stages of the C-O coupling reaction the CuSAr complex is converted into CuBr(PhSAr) via selective coupling of the monoanionic arenethiolato ligand with phenyl bromide with formation of CuBr. In addition, the first results are shown involving a multi-component reaction (MCR) protocol for the in situ synthesis of propargylamines and their subsequent conversion involving a C-O cross coupling reaction. Furthermore, two examples of sequential C-O/C-S and C-N/C-S cross coupling reactions have been carried out on the same dihalo-pyridine substrate in a one-pot process with the same (CuSAr) (pre-)catalyst (overall yields 40-80%).