352238-75-6

Basic information

• Product Name: (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol
• Synonyms: (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol
• CAS NO: 352238-75-6
• Molecular Weight: 431.488
• Mol File: 352238-75-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol(352238-75-6)
• EPA Substance Registry System: (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol(352238-75-6)

Safety Data

• Hazardous Substances Data: 352238-75-6(Hazardous Substances Data)

Upstream product

• 15248-39-2 6,7-dimethoxyisoquinoline 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 50299-95-1 2-benzoyl-1-cyano-6,7-dimethoxy-1,2-dihydroisoquinoline 

Downstream Products

• 352238-77-8 6,7-Dimethoxy-3'-benzyloxy-4'-methoxyoxobenzylisoquinoline 
• 352238-79-0 6,7-Dimethoxy-3'-hydroxy-4'-methoxyoxobenzylisoquinoline 
• 18694-10-5 1-(3'-hydroxy-4'-methoxybenzyl)-6,7-dimethoxyisoquinoline 

Relevant articles and documents

A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines

Methoxy- and benzyloxy-substituted isoquinolines are regioselectively metalated at C-1 with the Knochel-Hauser base, subsequent trapping with aromatic aldehydes gives aryl(isoquinolin-1-yl)carbinols as building blocks for divergent syntheses of different types of benzylisoquinoline alkaloids. Photochemical cyclization of ortho-bromo analogues under reductive conditions gives oxoaporphine alkaloids. Nine benzylisoquinoline alkaloids and two oxoaporphine alkaloids were obtained in two or three steps from appropriate isoquinolines.