35229-21-1

Basic information

• Product Name: Boc-Tyr(Bzl)-NH₂
• Synonyms: Boc-Tyr(Bzl)-NH₂
• CAS NO: 35229-21-1
• Molecular Weight: 370.448
• Mol File: 35229-21-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Boc-Tyr(Bzl)-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Tyr(Bzl)-NH₂(35229-21-1)
• EPA Substance Registry System: Boc-Tyr(Bzl)-NH₂(35229-21-1)

Safety Data

• Hazardous Substances Data: 35229-21-1(Hazardous Substances Data)

Upstream product

• 27513-44-6 N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester 
• 100-44-7 benzyl chloride 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 

Downstream Products

• 155163-73-8 3-(4-benzyloxyphenyl)propane-1,2-diamine 
• 869110-69-0 {[1-(4-benzyloxy-benzyl)-2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester 
• 909295-34-7 [1-aminomethyl-2-(4-benzyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 886758-82-3 {(S)-1-[(S)-2-(4-Benzyloxy-phenyl)-1-carbamoyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester 
• 73504-43-5 2-amino-3-(4-benzyloxyphenyl)propionamide 
• 244778-25-4 [2-(4-benzyloxy-phenyl)-1-cyano-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Mn(II) Complex of Lipophilic Group-Modified Ethylenediaminetetraacetic Acid (EDTA) as a New Hepatobiliary MRI Contrast Agent

Liver-specific contrast agents (CAs) can improve the Magnetic resonance imaging (MRI) detection of focal and diffuse liver lesions by increasing the lesion-to-liver contrast. A novel Mn(II) complex, Mn-BnO-TyrEDTA, with a lipophilic group-modified ethylenediaminetetraacetic acid (EDTA) structure as a ligand to regulate its behavior in vivo, is superior to Gd-EOB-DTPA in terms of a liver-specific MRI contrast agent. An MRI study on mice demonstrated that Mn-BnO-TyrEDTA can be rapidly taken up by hepatocytes with a combination of hepatobiliary and renal clearance pathways. Bromosulfophthalein (BSP) inhibition imaging, biodistribution, and cellular uptake studies confirmed that the mechanism of hepatic targeting of Mn-BnO-TyrEDTA is the hepatic uptake of the amphiphilic anion contrast agent mediated by organic anion transporting polypeptides (OATPs) expressed by functional hepatocytes.

Solid-phase synthesis of oligourea peptidomimetics

A procedure for the solid-phase synthesis of oligourea peptidomimetics starting from Boc-protected monomers is described. The compounds are prepared on Tentagel resin and can be obtained selectively rather as the C-terminal free acids with UV irradiation

Convenient Synthesis of N-Protected Amino Acid Amides

Boc- or Z-amino acids were conveniently amidated at room temperature by a one-pot procedure employing ammonium hydrogencarbonate and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in yields of 81-96percent.The benzyl ester-type protector for the side chains of aspartic acid and glutamic acid was not affected by the procedure.