35235-78-0

Basic information

• Product Name: C₂₃H₁₈N₃O₂P
• Synonyms: C₂₃H₁₈N₃O₂P
• CAS NO: 35235-78-0
• Molecular Weight: 399.389
• Mol File: 35235-78-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₈N₃O₂P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₈N₃O₂P(35235-78-0)
• EPA Substance Registry System: C₂₃H₁₈N₃O₂P(35235-78-0)

Safety Data

• Hazardous Substances Data: 35235-78-0(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 603-35-0 triphenylphosphine 
• 15009-92-4 2,5-dinitropyridine 
• 13892-06-3 N-trimethylsilyl(triphenylphosphoranylidene)amine 

Downstream Products

• 4214-76-0 5-nitro-pyridin-2-ylamine 

Relevant articles and documents

Highly efficient one-pot amination of carboxylate-substituted nitrogen-containing heteroaryl chlorides via Staudinger reaction

An efficient one-pot method for the synthesis of tert-butyl 6-aminonicotinate (5) is described. The key transformation involves displacement of the chloro group in tert-butyl 6-chloronicotinate (2) with azide followed by a Staudinger reaction. The scope of this methodology is further extended for the synthesis of a series of carboxylate-substituted heteroaryl amines. In particular, we synthesized tert-butyl carboxylate-substituted amino-pyridine, -pyridazine, and -pyrazine. In addition to one-pot conversion, short reaction time, simplicity of operation, ease of purification, and good yields are the key advantages of this methodology.