352542-64-4

Basic information

• Product Name: Carbamic acid, [4-(aminosulfonyl)phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 352542-64-4
• Molecular Formula: C11H16N2O4S
• Molecular Weight: 272.325
• Mol File: 352542-64-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [4-(aminosulfonyl)phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-(aminosulfonyl)phenyl]-, 1,1-dimethylethyl ester(352542-64-4)
• EPA Substance Registry System: Carbamic acid, [4-(aminosulfonyl)phenyl]-, 1,1-dimethylethyl ester(352542-64-4)

Safety Data

• Hazardous Substances Data: 352542-64-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 63-74-1 sulfanilamide 

Downstream Products

• 1449004-63-0 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-4-bromophenoxyacetamide 
• 1449004-62-9 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)phenylacetamide 
• 1449004-61-8 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)acetamide 
• 1449004-60-7 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-5-methylthiophen-2-carboxamide 
• 1449004-59-4 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)thiazole-2-carboxamide 
• 1449004-58-3 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)thiophen-2-carboxamide 
• 1449004-57-2 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)furan-2-carboxamide 
• 1449004-56-1 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-2-naphthamide 
• 1449004-55-0 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-3,4-dimethylbenzamide 
• 1449004-54-9 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-3-methylbenzamide 
• 1449004-53-8 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)biphenyl-4-carboxamide 
• 1449004-52-7 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-4-(trifluoromethyl)benzamide 
• 1449004-51-6 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-4-iodobenzamide 
• 1449004-50-5 N-(4-(N-(N-carbobenzoxy-L-phenylalanyl)sulfamoyl)-phenylcarbamothioyl)-4-bromobenzamide 

Relevant articles and documents

CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

This invention is in the area of cell cycle inhibiting compounds for the treatment of disorders involving abnormal cellular proliferation, and include selective CDK2 inhibitors for medical therapy and their pharmaceutically acceptable salts and compositions.

Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors

Human African trypanosomiasis (HAT) is one of the most neglected diseases in the tropic regions, which is fatal if not treated in time. There is an urgent need for new therapeutics, especially those in new chemical classes. Leucyl-tRNA synthetase (LeuRS) has been paid much attention as a recently clinically validated antimicrobial target. Our group has previously reported T. brucei LeuRS (TbLeuRS) inhibitors, including benzoxaboroles targeting the editing site and pyrrolinones targeting the synthetic site. Here we report the discovery of N-(4-sulfamoylphenyl)thioureas as a new class of TbLeuRS inhibitors. The R1 and R2 groups, reminiscent of the leucyl and adenyl regions of aa-AMP and aa-AMS, were optimized to result in a significant 13-fold increase of inhibitory activity (compound 19, IC 50 = 13.7 μM). Aided by ligand-protein docking, the 1,3-substitution at the central phenyl ring was predicted and proved to give significantly improved activity (59, IC50 = 1.1 μM). This work provided a new scaffold for the exploration of novel inhibitors against TbLeuRS, which may become potential therapeutics for the treatment of HAT.

7-MEMBERED RING COMPOUND, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF

A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.