3526-43-0

Basic information

• Product Name: (4-METHOXY-BENZYL)-PHENYL-AMINE
• Synonyms: (4-METHOXY-BENZYL)-PHENYL-AMINE;N-PHENYL-4-METHOXY BENZYLAMINE;4-METHOXY-N-PHENYL-BENZENEMETHANAMINE;OTAVA-BB 1371564;N-(4-Methoxybenzyl)aniline;4-METHOXY-N-PHENYLBENZYLAMINE
• CAS NO: 3526-43-0
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.27
• Mol File: 3526-43-0.mol
• Article Data: 390

Chemical Properties

• Boiling Point: 349.27 °C at 760 mmHg
• Flash Point: 141.735 °C
• Appearance: /
• Density: 1.102 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (4-METHOXY-BENZYL)-PHENYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHOXY-BENZYL)-PHENYL-AMINE(3526-43-0)
• EPA Substance Registry System: (4-METHOXY-BENZYL)-PHENYL-AMINE(3526-43-0)

Safety Data

• Hazardous Substances Data: 3526-43-0(Hazardous Substances Data)

Usage

General Description

"(4-Methoxy-benzyl)-phenyl-amine" is a type of organic compound known as an amine. This particular amine contains both a phenyl group and a methoxybenzyl group, meaning it contains a benzene ring with a methoxy group attached to one carbon and a benzyl group attached to another carbon. Amines are derivatives of ammonia, where one or more hydrogen atoms have been replaced by a substituent (in this case, the methoxybenzyl and phenyl groups). They have range of applications in industry and medicine such as in the manufacturing of drugs, dyes, polymers, and other chemicals. The unique properties and reactivity of (4-Methoxy-benzyl)-phenyl-amine can make it useful in scientific research or industrial applications.

Upstream product

• 50-00-0 formaldehyd 
• 100-66-3 methoxybenzene 
• 62-53-3 aniline 
• 824-94-2 p-methoxybenzyl chloride 
• 105-13-5 4-Methoxybenzyl alcohol 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 91-78-1 1,3,5-triphenylhexahydro-1,3,5-triazine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 123-11-5 4-methoxy-benzaldehyde 
• 4028-53-9 benzyl p-nitrobenzenesulphonate 
• 104-94-9 4-methoxy-aniline 
• 56644-00-9 N-(4-methoxybenzylidene)cyclohexylamine 
• 56644-00-9 (E)-N-cyclohexyl-1-(4-methoxyphenyl)methanimine 
• 39070-63-8 4-benzoylbenzene-1,2-diamine 

Downstream Products

• 102166-98-3 N-(4-methoxy-benzyl)-N-(1-methyl-[4]piperidyl)-aniline 
• 119210-87-6 diisopropyl-{2-[(4-methoxy-benzyl)-phenyl-carbamoyloxy]-ethyl}-methyl-ammonium; iodide 
• 102453-47-4 N-(4-methoxy-benzyl)-N-(2-piperidino-ethyl)-aniline 
• 113183-81-6 N²-(4-methoxy-benzyl)-N¹,N¹,N³,N³-tetramethyl-N²-phenyl-propane-1,2,3-triyltriamine 
• 5705-09-9 N-(4-methoxybenzyl)-N-nitrosoaniline 
• 90521-77-0 5-nitro-N-(4-methoxybenzyl)-N-phenylimidazole-4-carboxamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 175687-75-9 ethyl 2-diazo-3-((4-methoxybenzyl)(phenyl)amino)-3-oxopropanoate 
• 758640-21-0 N-Benzylaniline 
• 864784-00-9 N-(4-methoxybenzyl)-N-phenyl but-2-ynamide 
• 1613-96-3 N-(4-methoxybenzylidene)aniline 

Relevant articles and documents

N1[P(OPH)3]4 catalyzed transfer hydrogenation using HCOONH4

Ni[P(OPh)3]4 was found to catalyze the transfer hydrogenation of various organic functional groups using HCOONH4.

An Insight into Transfer Hydrogenation Reactions Catalysed by Iridium(III) Bis-N-heterocyclic Carbenes

A variety of [M(L)2(L′)2{κC,C′-bis(NHC)}]BF4 complexes (M = Rh or Ir; L = CH3CN or wingtip group; L′ = I- or CF3COO-; NHC=N-heterocyclic carbene) have been tested as pre-catalyst

Hydroboration and reductive amination of ketones and aldehydes with HBpin by a bench stable Pd(ii)-catalyst

A palladium(ii) complex [(κ4-{1,2-C6H4(NCH-C6H4O)2}Pd] (1) supported by a dianionic salen ligand [1,2-C6H4(NCH-C6H4O)2]2- (L) was synthesised and used as a molecular pre-catalyst in the hydroboration of aldehydes and ketones. The molecular structure of Pd(ii) complex 1 was established by single-crystal X-ray diffraction analysis. Complex 1 was tested as a competent pre-catalyst in the hydroboration of aldehydes and ketones with pinacolborane (HBpin) to produce corresponding boronate esters in excellent yields at ambient temperature under solvent-free conditions. Further, the complex 1 proved to be a competent catalyst in the reductive amination of aldehydes with HBpin and primary amines under mild and solvent-free conditions to afford a high yield (up to 97%) of corresponding secondary amines. Both protocols provided high conversion, superior selectivity and broad substrate scope, from electron-withdrawing to electron-donating and heterocyclic substitutions. A computational study based on density functional theory (DFT) revealed a reaction mechanism for Pd-catalysed hydroboration of carbonyl species in the presence of HBpin. The protocols also uncovered the dual role of HBpin in achieving the hydroboration reaction.

Mechanistic Insight into Hydroboration of Imines from Combined Computational and Experimental Studies

Boron Lewis acid-catalyzed and catalyst-free hydroboration reactions of imines are attractive due to the mild reaction conditions. In this work, the mechanistic details of the hydroboration reactions of two different kinds of imines with pinacolborane (HB