352672-09-4Relevant articles and documents
Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)
Tasler, Stefan,Kraus, Juergen,Pegoraro, Stefano,Aschenbrenner, Andrea,Poggesi, Elena,Testa, Rodolfo,Motta, Gianni,Leonardi, Amedeo
, p. 2876 - 2880 (2007/10/03)
Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan technology, a new lead series was identified and further structurally investigated. Ki's as low as around 100 nM were achieved.