35283-05-7

Basic information

• Product Name: (4-amino-phenyl)-propiolic acid
• Synonyms: (4-amino-phenyl)-propiolic acid
• CAS NO: 35283-05-7
• Molecular Weight: 161.16
• Mol File: 35283-05-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (4-amino-phenyl)-propiolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-amino-phenyl)-propiolic acid(35283-05-7)
• EPA Substance Registry System: (4-amino-phenyl)-propiolic acid(35283-05-7)

Safety Data

• Hazardous Substances Data: 35283-05-7(Hazardous Substances Data)

Usage

Description

(4-amino-phenyl)-propiolic acid is a chemical compound with the molecular formula C9H7NO2. It is a propiolic acid derivative with a 4-amino-phenyl group attached to the propiolic acid structure. (4-amino-phenyl)-propiolic acid is a white solid at room temperature and is sparingly soluble in water. The presence of both an amino and a propiolic acid group in the molecule gives it potential for use in a variety of chemical reactions and applications.

Uses

Used in Organic Synthesis:
(4-amino-phenyl)-propiolic acid is used as a building block in organic synthesis for its ability to participate in various chemical reactions due to the presence of both an amino and a propiolic acid group.
Used in Pharmaceutical Research:
(4-amino-phenyl)-propiolic acid is used as a starting material in pharmaceutical research for the development of new drugs, taking advantage of its unique chemical properties and reactivity.
Used in Production of Functional Materials:
(4-amino-phenyl)-propiolic acid is used as a component in the production of various functional materials, leveraging its chemical structure to create materials with specific properties for different applications.

Upstream product

• 124-38-9 carbon dioxide 
• 14235-81-5 4-Ethynylaniline 
• 159217-89-7 N-Boc-4-iodoaniline 
• 471-25-0 Propiolic acid 
• 106-40-1 4-bromo-aniline 
• 2216-24-2 3-(4-nitrophenyl)-2-propynoic acid 

Downstream Products

• 99-92-3 p-aminobenzophenone 
• 1849-25-8 4-phenylethynylphenylamine 

Relevant articles and documents

Central Doping of a Foreign Atom into the Silver Cluster for Catalytic Conversion of CO2 toward C?C Bond Formation

Clusters with an exact number of atoms are of particular interest in catalysis. Their catalytic behaviors can be potentially altered with the addition or removal of a single atom. Now the effects of doping with a single foreign atom (Au, Pd, and Pt) into the core of an Ag cluster with 25 atoms on the catalytic properties are explored, where the foreign atom is protected by 24 Ag atoms (Au@Ag24, Pd@Ag24, and Pt@Ag24). The central doping of a single atom into the Ag25 cluster has a substantial influence on the catalytic performance in the carboxylation reaction of CO2 with terminal alkyne through C?C bond formation to produce propiolic acid. These studies reveal that the catalytic properties of the cluster catalysts can be dramatically changed with the subtle alteration by a single atom away from the active sites.

Practical synthesis of unsymmetrical diarylacetylenes from propiolic acid and two different aryl bromides

A palladium catalyst that mediates the one-pot sequential Sonogashira and decarboxylative coupling of propiolic acid with two different aryl bromides has been developed. Selective coupling of the first aryl bromide was achieved in the presence of a copper-free, monometallic catalyst generated in situ from allylpalladium chloride dimer and SPhos with tetra-n-butylammonium fluoride as the base in an N-methyl-2-pyrrolidone/water solvent mixture. Upon addition of another aryl bromide and raising the temperature from 50 to 80°C, the intermediate arylpropiolic acid underwent decarboxylative coupling to give the corresponding diarylacetylene. Thus, the new system permits a one-pot three-component synthesis of unsymmetrical diarylacetylenes from widely available aryl bromides, rather than expensive aryl iodides, and propiolic acid, rather than (trimethylsilyl)acetylene, as an inexpensive and easy-to-handle acetylene synthon. The process is highly selective, modular, and gives access to a wide range of unsymmetrical diarylacetylenes in good yields. A palladium-catalyzed three component synthesis of diaryl acetylenes has been optimized. Several disubstituted alkynes have been prepared from two different arylbromides and propiolic acid in good yields. Copyright

Antiatherosclerotic and hypolipidemic 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives

This disclosure describes novel 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives useful as hypolipidemic and antiatherosclerotic agents.