35283-09-1 Usage
Description
(3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is a chemical compound with the molecular formula C11H9NO4. It is a nitrophenyl derivative of propynoic acid with an ethyl ester group, known for its potential applications in organic synthesis and pharmaceutical research.
Uses
Used in Organic Synthesis:
(3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is used as a building block for creating diverse molecules with potential biological activities. Its unique structure allows for further chemical modifications, making it a valuable component in the synthesis of various organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is used as a key intermediate in the development of new drugs. Its nitrophenyl and propynoic acid moieties contribute to its interesting chemical and pharmacological properties, which can be exploited to design and synthesize novel therapeutic agents.
Used in Structure-Activity Relationship Studies:
(3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is also utilized in the study of structure-activity relationships. By examining the effects of modifications to this compound, researchers can gain insights into the relationship between a molecule's structure and its biological activity, which is crucial for the design of more effective drugs.
Used in Organic Solvents:
Due to the presence of the ethyl ester group, (3-NITRO-PHENYL)-PROPYNOIC ACID ETHYL ESTER is suitable for use in organic solvents. This property makes it a valuable component in various chemical processes and reactions where organic solvents are required.
Check Digit Verification of cas no
The CAS Registry Mumber 35283-09-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,2,8 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 35283-09:
(7*3)+(6*5)+(5*2)+(4*8)+(3*3)+(2*0)+(1*9)=111
111 % 10 = 1
So 35283-09-1 is a valid CAS Registry Number.
35283-09-1Relevant articles and documents
Concise Synthesis of Furo[2,3- b ]indolines via [3,3]-Sigmatropic Rearrangement of N -Alkenyloxyindoles
Shevlin, Michael,Strotman, Neil A.,Anderson, Laura L.
supporting information, p. 197 - 201 (2020/09/21)
A concise new synthetic route to furo[2,3- b ]indolines has been developed by taking advantage of the reactivity of N -alkenyloxyindole intermediates. These compounds spontaneously undergo [3,3]-sigmatropic rearrangement followed by cyclization to form hemiaminals as single diastereomers. Tin-promoted N -hydroxyindole formation followed by conjugate addition to activated alkynes provides simple and modular access to a diverse array of N -alkenyloxyindoles and their corresponding furo[2,3- b ]indolines. Microscale high-throughput experimentation was used to facilitate investigation of the scope and tolerance of this transformation and related studies on the nucleophilic aromatic substitution and rearrangement of N -hydroxyindoles with halogenated arenes have also been evaluated.
(Ethoxycarbonyliodomethyl)triphenylphosphonium Iodide: A Convenient Reagent for the Direct Synthesis of β-Substituted Propiolic Acids via the Corresponding Esters
Chenault, Jaques,Dupin, Jean-Francois E.
, p. 498 - 499 (2007/10/02)
Reaction between (ethoxycarbonyliodomethyl)triphenylphosphonium iodide, potassium carbonate, and various aromatic or aliphatic aldehydes in a liquid solid two phases system gives β-substituted propiolic esters.The corresponding acids are obtained in good yield by hydrolysis.
