35285-54-2 Usage
Description
N-hydroxy-N-methylglycine, also known as sarcosine, is a chemical compound that serves as an intermediate in the metabolism of choline. It is a derivative of glycine and functions as a precursor in the synthesis of various important molecules in the body, including creatine and proteins. Sarcosine has been studied for its potential therapeutic effects in conditions such as schizophrenia, depression, and prostate cancer. Furthermore, it has been utilized as a biomarker for differentiating between benign and malignant prostate tissues. Overall, N-hydroxy-N-methylglycine holds promise for a range of applications in medicine and biochemistry.
Uses
Used in Pharmaceutical Applications:
N-hydroxy-N-methylglycine is used as a therapeutic agent for the treatment of conditions such as schizophrenia, depression, and prostate cancer. Its potential therapeutic effects are attributed to its ability to modulate various biological pathways and mechanisms involved in these conditions.
Used in Biochemical Research:
N-hydroxy-N-methylglycine is used as a biochemical research tool for studying the metabolism of choline and the synthesis of important molecules in the body, such as creatine and proteins. Its role as a precursor in these processes makes it a valuable compound for understanding the underlying mechanisms of various biological functions.
Used in Diagnostic Applications:
N-hydroxy-N-methylglycine is used as a biomarker for differentiating between benign and malignant prostate tissues. Its ability to distinguish between these tissue types aids in the accurate diagnosis and treatment of prostate cancer.
Used in Nutritional Supplements:
N-hydroxy-N-methylglycine is used as a nutritional supplement to support the synthesis of creatine and proteins in the body. Its role as a precursor in these processes contributes to maintaining optimal muscle function and overall health.
Used in Cosmetics Industry:
N-hydroxy-N-methylglycine is used as an ingredient in cosmetics for its potential skin conditioning and moisturizing properties. Its ability to interact with biopolymers and macromolecules in the skin may contribute to improved skin health and appearance.
Check Digit Verification of cas no
The CAS Registry Mumber 35285-54-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,2,8 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 35285-54:
(7*3)+(6*5)+(5*2)+(4*8)+(3*5)+(2*5)+(1*4)=122
122 % 10 = 2
So 35285-54-2 is a valid CAS Registry Number.
35285-54-2Relevant articles and documents
Is N,N-dimethylglycine N-oxide a choline and betaine metabolite?
Lever, Michael,McEntyre, Christopher J.,George, Peter M.,Chambers, Stephen T.
, p. 775 - 784 (2017)
Choline metabolism is by oxidation to betaine, which is demethylated to N,N-dimethylglycine; dimethylglycine is oxidatively demethylated to sarcosine. This pathway is important for osmoregulation and as a source of methyl groups. We asked whether another metabolite was involved. We synthesized the N-oxide of dimethylglycine (DMGO) by oxidizing dimethylglycine with peracetic acid, and measured DMGO in human plasma and urine by HPLC-MS/MS with positive ion detection, using two chromatography procedures, based on ion exchange and HILIC separations. The molecular ion DMGOH+ (m/z=120) yielded four significant fragments (m/z=103, 102, 58 and 42). The suspected DMGO peak in human body fluids showed all these fragments, and co-chromatographed with added standard DMGO in both HPLC systems. Typical plasma concentrations of DMGO are under 1 μmol/l. They may be lower in metabolic syndrome patients. Urine concentrations are higher, and DMGO has a higher fractional clearance than dimethylglycine, betaine and choline. It was present in all of over 80 human urine and plasma samples assayed. Plasma DMGO concentrations correlate with plasma DMG concentrations, with betaine and choline concentrations, with the osmolyte myo-inositol, and strongly with urinary DMGO excretion. We conclude that DMGO is probably a normal human metabolite.
