3537-09-5 Usage
General Description
6-NITRO-3H-IMIDAZO[4,5-B]PYRIDINE is a chemical compound with a molecular formula C7H4N4O2. It is a nitroimidazole derivative with potential antineoplastic and radiosensitizing activities. 6-NITRO-3H-IMIDAZO[4,5-B]PYRIDINE has been studied for its potential use in the treatment of various types of cancer, including brain tumors, cervical cancer, and head and neck cancer, by acting as a radiosensitizer to enhance the effects of radiation therapy. Additionally, it has been investigated for its potential to selectively target hypoxic tumor cells, which are often resistant to radiation therapy and chemotherapy. 6-NITRO-3H-IMIDAZO[4,5-B]PYRIDINE is also a known mutagen and genotoxic agent, and precautions are necessary for its handling and disposal.
Check Digit Verification of cas no
The CAS Registry Mumber 3537-09-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,3 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3537-09:
(6*3)+(5*5)+(4*3)+(3*7)+(2*0)+(1*9)=85
85 % 10 = 5
So 3537-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H4N4O2/c11-10(12)4-1-5-6(7-2-4)9-3-8-5/h1-3H,(H,7,8,9)
3537-09-5Relevant articles and documents
Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase
Newhouse, Bradley J.,Wenglowsky, Steve,Grina, Jonas,Laird, Ellen R.,Voegtli, Walter C.,Ren, Li,Ahrendt, Kateri,Buckmelter, Alex,Gloor, Susan L.,Klopfenstein, Nathalie,Rudolph, Joachim,Wen, Zhaoyang,Li, Xianfeng,Feng, Bainian
, p. 5896 - 5899 (2013/10/22)
This Letter details the synthesis and evaluation of imidazo[4,5-b]pyridines as inhibitors of B-Raf kinase. These compounds bind in a DFG-in, αC-helix out conformation of B-Raf, which is a binding mode associated with significant kinase selectivity. Structure-activity relationship studies involved optimization of the ATP-cleft binding region of these molecules, and led to compound 23, an inhibitor with excellent enzyme/cell potency, and kinase selectivity.
