3543-01-9

Basic information

• Product Name: 3-Amino-5-hydroxypyridine
• Synonyms: 5-AMINO-PYRIDIN-3-OL;3-AMINO-5-HYDROXYPYRIDINE;3-Amino-5-hydroxypyridine dihydrochloride;3-Hydroxy-5-Aminopyridine;3-Amino-5-hydroxypyridrine;5-AMINO-PYRIDIN-3-OL,97%;5-Aminopyridin-3-ol dihydrochloride
• CAS NO: 3543-01-9
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• Product Categories: pharmacetical;Pyridine series;Pyridine;Pyridines;Heterocycle-Pyridine series
• Mol File: 3543-01-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 447.412 °C at 760 mmHg
• Flash Point: 224.387 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 1.28E-08mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 5.41±0.10(Predicted)
• CAS DataBase Reference: 3-Amino-5-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-5-hydroxypyridine(3543-01-9)
• EPA Substance Registry System: 3-Amino-5-hydroxypyridine(3543-01-9)

Safety Data

• Hazardous Substances Data: 3543-01-9(Hazardous Substances Data)

Usage

Chemical Properties

brown powder

InChI:InChI=1/C5H6N2O/c6-4-1-5(8)3-7-2-4/h1-3,8H,6H2

Upstream product

• 74115-13-2 5-bromopyridine-3-ol 

Downstream Products

• 186593-26-0 5-nitropyridin-3-ol 

Relevant articles and documents

Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-5-amino/ methylaminopiperidin-1-yl)fluoroquinolone derivatives

We report herein the design and synthesis of novel 7-(3-alkoxyimino-5- amino/methylaminopiperidin-1-yl)fluoroquinolone derivatives based on the structures of new fluoroquinolones IMB and DZH. The antibacterial activity of these newly synthesized compounds was also evaluated and compared with gemifloxacin, ciprofloxacin, and levofloxacin. Results revealed that all of the target compounds 10-27 have good potency in inhibiting the growth of Staphylococcus aureus including MSSA (MIC: 0.125-8 μg/mL), Staphylococcus epidermidis including MRSE (MIC: 0.25-16 μg/mL), Streptococcus pneumoniae (MIC: 0.125-4 μg/mL), and Escherichia coli (MIC: 0.25-0.5 μg/mL). In particular, some compounds showed useful activity against several fluoroquinolone-resistant strains, and the most active compound 15 was found to be 16-128, 2-32, and 4-8-fold more potent than the three reference drugs against fluoroquinolone-resistant MSSA, MRSA, and MRSE.