35455-86-8

Basic information

• Product Name: 1-Methyl-4-thioxo-3,4-dihydropyrimidine-2(1H)-one
• Synonyms: 1-Methyl-3,4-dihydro-4-thioxopyrimidine 2(1H)-one;1-Methyl-3,4-dihydro-4-thioxopyrimidine-2(1H)-one;1-Methyl-4(3H)-thioxopyrimidine-2(1H)-one;1-Methyl-4-thiouracil;1-Methyl-4-thioxo-1,2,3,4-tetrahydropyrimidine-2-one;1-Methyl-4-thioxo-3,4-dihydropyrimidine-2(1H)-one
• CAS NO: 35455-86-8
• Molecular Formula: C₅H₆N₂OS
• Molecular Weight: 142.18
• Mol File: 35455-86-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-4-thioxo-3,4-dihydropyrimidine-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-thioxo-3,4-dihydropyrimidine-2(1H)-one(35455-86-8)
• EPA Substance Registry System: 1-Methyl-4-thioxo-3,4-dihydropyrimidine-2(1H)-one(35455-86-8)

Safety Data

• Hazardous Substances Data: 35455-86-8(Hazardous Substances Data)

Upstream product

• 615-77-0 1-methyluracil 
• 49844-94-2 1-methyl-4-(methylsulfanyl)pyrimidin-2(1H)-one 
• 22576-11-0 1-methyl-4-(methylsulfanyl)pyrimidine-2(1H)-thione 

Downstream Products

• 1122-47-0 1-MeCyt 
• 74203-17-1 4-[2-(4-Bromo-phenyl)-2-oxo-ethylsulfanyl]-1-methyl-1H-pyrimidin-2-one 
• 263551-24-2 C₁₃H₁₀N₂O₂S 
• 74195-35-0 1-Methyl-4(3H)-<(4-bromobenzoyl)methenyl>-2-pyrimidinone 

Relevant articles and documents

Straightforward pyrimidine ring construction: A versatile tool for the synthesis of nucleobase and nucleoside analogues

A general route to 1,2,4-trisubstituted pyrimidines is described in one to three steps from a common key precursor, diazadienium iodide 2. An efficient preliminary [4+2] cyclocondensation reaction between the azabutadiene building block 2 and various iso(thio)cyanates constitutes an original construction of the pyrimidine skeleton. Subsequent structural modifications on the heterocycle allow the elaboration of a 1-substituted pyrimidine library that includes nucleoside analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Isolation and characterization of pyrimidine sulfenic acid via scission of the sulfur-sulfur bond in the methyl analog of bis(4-thiouridine) disulfide.

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