35467-65-3

Basic information

• Product Name: P-METHYLPHENYLHYDRAZINE HCL
• Synonyms: P-METHYLPHENYLHYDRAZINE HCL;Hydrazine, (4-methylphenyl)-, hyrochloride
• CAS NO: 35467-65-3
• Molecular Formula: C7H11ClN2
• Molecular Weight: 158.62864
• EINECS: 211-295-2
• Mol File: 35467-65-3.mol
• Article Data: 30

Chemical Properties

• Melting Point: 241℃
• Appearance: /
• Water Solubility: soluble
• CAS DataBase Reference: P-METHYLPHENYLHYDRAZINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: P-METHYLPHENYLHYDRAZINE HCL(35467-65-3)
• EPA Substance Registry System: P-METHYLPHENYLHYDRAZINE HCL(35467-65-3)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:; R36/37/38:; R40:
• Safety Statements: S26:; S36/37/39:
• Hazardous Substances Data: 35467-65-3(Hazardous Substances Data)

Usage

General Description

P-Methylphenylhydrazine HCl is a chemical compound that is commonly used in the pharmaceutical and research industries. It is a hydrazine derivative, which is a class of chemicals known for their diverse range of biological and industrial applications. P-Methylphenylhydrazine HCl is primarily used as a reagent in the synthesis of various organic compounds and as a precursor in the production of pharmaceutical drugs. It is also utilized in research and development processes, particularly in the study of hydrazine derivatives and their potential applications in medicine and materials science. In addition, P-Methylphenylhydrazine HCl has been investigated for its potential anticancer and antitumor properties, making it a subject of interest in cancer research.

InChI:InChI=1/C7H10N2.ClH/c1-6-2-4-7(9-8)5-3-6;/h2-5,9H,8H2,1H3;1H

Upstream product

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• 3483-19-0 3-(4-methylphenyl)sydnone 
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• 106-38-7 para-bromotoluene 
• 624-31-7 4-tolyl iodide 
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• 539-44-6 N-4-methylphenylhydrazine 

Downstream Products

• 107552-50-1 furfural-p-tolylhydrazone 
• 107521-82-4 7-chloro-4-methyl-5-nitro-2-p-tolyl-2H-benzotriazole 
• 107410-42-4 5-methyl-6-nitro-2-p-tolyl-2H-benzotriazole 
• 7382-40-3 p-methylphenyl thiosemicarbazide 
• 89314-29-4 2-p-tolylhydrazono-propionic acid 
• 136984-61-7 (E)-3-(p-tolylhydrazono)-2-butanone 
• 109442-43-5 1-p-tolyl-1H-[1,2,4]triazole-3,5-diyldiamine 
• 54624-18-9 10-(p-tolueneazo)-9-phenanthrol 
• 5098-99-7 4-(4'-Methylphenylazo)-1-naphthol 
• 96984-69-9 7-Methyl-4H-2,3-dihydrothieno<3,2-b>indol 
• 14120-25-3 8-methyl-1,3,4,5-tetrahydrothiopyran[4,3-b]indole 
• 33177-03-6 9-methyl-7,12-dihydro-6H-benzo[2,3]oxepino[4,5-b]indole 
• 70092-84-1 5,5-Dimethyl-3-oxo-1-p-tolylhydrazino-1-cyclohexen 
• 67420-42-2 4-(3,5-dimethyl-1-p-tolyl-1H-pyrazol-4-ylazo)-N-thiazol-2-yl-benzenesulfonamide 

Relevant articles and documents

Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode

A series of novel 2,6-dimethyl-4-aminopyrimidine hydrazones 5 were rationally designed and synthesized as pyruvate dehydrogenase complex E1 (PDHc-E1) inhibitors. Compounds 5 strongly inhibited Escherichia coli (E. coli) PDHc-E1 (IC50 values 0.94-15.80 μM). As revealed by molecular docking, site-directed mutagenesis, enzymatic, and inhibition kinetic analyses, compounds 5 competitively inhibited PDHc-E1 and bound in a "straight"pattern at the E. coli PDHc-E1 active site, which is a new binding mode. In in vitro antifungal assays, most compounds 5 at 50 μg/mL showed more than 80% inhibition against the mycelial growth of six tested phytopathogenic fungi, including Botrytis cinerea, Monilia fructigena, Colletotrichum gloeosporioides, andBotryosphaeria dothidea. Notably, 5f and 5i were 1.8-380 fold more potent against M. fructigena than the commercial fungicides captan and chlorothalonil. In vivo, 5f and 5i controlled the growth of M. fructigena comparably to the commercial fungicide tebuconazole. Thus, 5f and 5i have potential commercial value for the control of peach brown rot caused by M. fructigena.

Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents

A series of tryptamine salicylic acid derivatives were synthesized and their antiproliferative activity against MGC-803, MCF-7, HepG2, A549 and HeLa cell lines was evaluated. The structure-activity relationship (SAR) study revealed that different substitutions of the C5 and C3′-C5′ positions have certain effects on the anti-proliferation activity. The growth assay revealed that N-[2-(5-bromo-1H-indol-3-yl)-ethyl]-2-hydroxy-3-methyl-benzamide (E20) showed the most potent and broad-spectrum anticancer inhibition of all the cell lines evaluated, and was only more potent than 5-Fu for the gastric cancer cell line. Preliminary studies indicated that compound E20 could inhibit colony formation and migration of MGC-803 cells. The flow cytometry (FCM) results showed that compound E20 arrested the cell cycle in the G2/M phase and induced apoptosis of MGC-803 cells in a concentration-dependent manner. In addition, the western blot results showed that E20 can down-regulate the expression of hexokinase 2. Our studies suggest that the framework of N-[2-(5-bromo-1H-indol-3-yl)-ethyl]-2-hydroxy-3-methyl-benzamide may be consider as a new type of chemical for designing effective anti-cancer drugs targeting gastric cancer cells.

Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.