35486-97-6Relevant articles and documents
Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies
Della Volpe, Serena,Nasti, Rita,Queirolo, Michele,Unver, M. Yagiz,Jumde, Varsha K.,D?mling, Alexander,Vasile, Francesca,Potenza, Donatella,Ambrosio, Francesca Alessandra,Costa, Giosué,Alcaro, Stefano,Zucal, Chiara,Provenzani, Alessandro,Di Giacomo, Marcello,Rossi, Daniela,Hirsch, Anna K. H.,Collina, Simona
, p. 615 - 620 (2019)
The key role of RNA-binding proteins (RBPs) in regulating post-transcriptional processes and their involvement in several pathologies (i.e., cancer and neurodegeneration) have highlighted their potential as therapeutic targets. In this scenario, Embryonic Lethal Abnormal Vision (ELAV) or Hu proteins and their complexes with target mRNAs have been gaining growing attention. Compounds able to modulate the complex stability could constitute an innovative pharmacological strategy for the treatment of numerous diseases. Nevertheless, medicinal-chemistry efforts aimed at developing such compounds are still at an early stage. As part of our ongoing research in this field, we hereby present the rational design and synthesis of structurally novel HuR ligands, potentially acting as HuR-RNA interferers. The following assessment of the structural features of their interaction with HuR, combining saturation-transfer difference NMR and in silico studies, provides a guide for further research on the development of new effective interfering compounds of the HuR-RNA complex.
A BISPHENOL DERIVATIVE HAVING AN ESTER BOND
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, (2018/06/13)
PROBLEM TO BE SOLVED: To provide a production intermediate useful for obtaining a compound having an ester bond, and a production method to obtain a compound having an ester bond, using the same, with convenience and high purity; specifically, to provide a bisphenol derivative having an ester bond, a method for producing the same, and a compound produced from the bisphenol derivative as an intermediate; and to further provide a polymer obtained by the polymerization of a polymerizable composition containing the compound produced from the bisphenol derivative as an intermediate, and an optical anisotropic body using the polymer. SOLUTION: A bisphenol derivative having an ester bond is represented by general formula (I-C), where at least one of A1 and A2 is substituted with one substituent L. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT
Additive components for liquid crystalline materials
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, (2012/02/05)
The present invention relates to mesogenic, cross-linkable mixtures comprising (i) a cross-linkable liquid crystalline host compound comprising at least one cross-linkable liquid crystalline compound, and (ii) at least one chiral or achiral rod shaped additive component, wherein said additive component has a rigid core and comprises at least two fused or linked, optionally substituted, non-aromatic, aromatic, carbocyclic or heterocyclic groups, and also comprises at least one optionally substituted alkyl residue, and at least one polymerizable group and wherein the additive component has a transition temperature to the isotropic state of 40° C. or lower. The invention also relates to the novel chiral or achiral rod-shaped additive compounds used for the preparation of these mixtures, to mixtures according to the invention in form of an elastomer, polymer gel, polymer network or polymer film, to polymer networks and liquid crystalline polymer films prepared from these mixtures and to optical or electrooptical components comprising polymer networks and liquid crystalline polymer films prepared from such mixtures. Further, the invention relates to the use of the chiral or achiral rod shaped compounds as components of a cross-linkable liquid crystalline mixture in the production of orientated liquid crystalline polymers, to liquid crystalline mixtures comprising these compounds, to liquid crystalline polymers and liquid crystalline polymer networks prepared from such liquid crystalline mixtures, and to liquid crystalline devices comprising these compounds.
