35488-00-7

Basic information

• Product Name: 1-Methyl-1,2,3,4-tetrahydropyridine-4-one
• Synonyms: 1-Methyl-1,2,3,4-tetrahydropyridine-4-one;2,3-Dihydro-1-methylpyridin-4(1H)-one
• CAS NO: 35488-00-7
• Molecular Formula: C₆H₉NO
• Molecular Weight: 111.14
• Mol File: 35488-00-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 102 °C(Press: 0.7 Torr)
• Appearance: /
• Density: 1.035±0.06 g/cm3(Predicted)
• PKA: 4.33±0.20(Predicted)
• CAS DataBase Reference: 1-Methyl-1,2,3,4-tetrahydropyridine-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1,2,3,4-tetrahydropyridine-4-one(35488-00-7)
• EPA Substance Registry System: 1-Methyl-1,2,3,4-tetrahydropyridine-4-one(35488-00-7)

Safety Data

• Hazardous Substances Data: 35488-00-7(Hazardous Substances Data)

Usage

Molecular structure

A heterocyclic compound consisting of a six-membered pyridine ring with a double bond between two carbon atoms, and a methyl group attached to the first carbon.

Neurotoxic effects

Selectively destroys dopamine-producing neurons in the substantia nigra region of the brain, leading to symptoms similar to Parkinson's disease.

Research use

Often used to create animal models of Parkinson's disease and to study the mechanisms of dopaminergic neuron degeneration.

Human exposure

Linked to cases of parkinsonism in individuals who have been exposed to illicitly produced MPTP derivatives.

Regulation

MPTP and its derivatives are tightly controlled substances that require special handling and permits for use in research and pharmaceutical applications.

Upstream product

• 695-19-2 N-methyl-4-pyridone 
• 1445-73-4 1-Methyl-4-piperidone 
• 116414-58-5 4-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-3,6-dihydro-2H-pyridine 1-oxide 
• 28286-05-7 8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan 
• 73390-09-7 4,4-Dihydroxy-1-methylpiperidinium-chlorid 
• 27248-04-0 4-((trimethylsilyl)oxy)pyridine 
• 116414-57-4 4-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-1,2,3,6-tetrahydro-pyridine 
• 57330-84-4 ethyl 3,4-dihydro-4-oxo-1(2H)-pyridinecarboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 46826-37-3 2-(4-methoxy-benzyl)-1-methyl-piperidin-4-one 
• 116414-61-0 2-(4-Methoxy-benzyl)-1,4-dimethyl-piperidin-4-ol 
• 116440-58-5 Acetic acid 1-methyl-6-phenylethynyl-1,2,3,6-tetrahydro-pyridin-4-yl ester 
• 116414-59-6 Acetic acid 6-(4-methoxy-benzyl)-1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl ester 
• 1572373-72-8 6-(4-methoxyphenyl)-1-methyl-2,3-dihydropyridin-4(1H)-one 

Relevant articles and documents

A Visible-Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex

Through a rapid screening of Cp*Ir complexes based on a turn-on type fluorescence readout, a [Cp*Ir(dipyrido[3,2-a : 2’,3’-c]phenazine)Cl]+ complex was found to catalyze the blue-light promoted dehydrogenation of N-heterocycles under physiological conditions. In the dehydrogenation of tetrahydroisoquinolines, the catalyst preferentially yielded the monodehydrogenated product, accompanying H2O2 generation. We surmise that this mechanism may be reminiscent of flavin-dependent oxidases.

Gold nanoparticles on OMS-2 for heterogeneously catalyzed aerobic oxidative α,β-dehydrogenation of β-heteroatom-substituted ketones

In the presence of Au nanoparticles supported on manganese oxide OMS-2 (Au/OMS-2), various kinds of β-heteroatom-substituted α,β-unsaturated ketones (heteroatom = N, O, S) can be synthesized through α,β-dehydrogenation of the corresponding saturated ketones using O2 (in air) as the oxidant. The catalysis of Au/OMS-2 is truly heterogeneous, and the catalyst can be reused.

Hydroxy Chalcogenide-Promoted Morita-Baylis-Hillman Alkylation Reaction: Intermolecular Applications with Alkyl Halides as Electrophiles

Hydroxysulfides acted as catalysts to promote the Morita-Baylis-Hillman alkylation reaction of cyclohexenones and dihydropyridinones. The procedure worked efficiently with a variety of halides as electrophiles. Side reactions were in competition with the