355-28-2

Basic information

• Product Name: 1H,1H-PERFLUOROPENTAN-1-OL
• Synonyms: 1H,1H-NONAFLUOROHEPTAN-1-OL;1H,1H-NONAFLUOROPENTAN-1-OL;1H,1H-NONAFLUOROPENTANOL-1;1H,1H-PERFLUOROPENTAN-1-OL;4:1 FTOH;1H,1H-Nonafluoropentan-1-ol 97%;1H,1H-Nonafluoropentan-1-ol97%;(Perfluorobutyl)methanol
• CAS NO: 355-28-2
• Molecular Formula: C₅H₃F₉O
• Molecular Weight: 250.06
• Mol File: 355-28-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 110-111°C
• Flash Point: 9.9 °C
• Appearance: /
• Density: 1,664 g/cm3
• Vapor Pressure: 30.6mmHg at 25°C
• Refractive Index: 1.3
• PKA: 12.58±0.10(Predicted)
• CAS DataBase Reference: 1H,1H-PERFLUOROPENTAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1H,1H-PERFLUOROPENTAN-1-OL(355-28-2)
• EPA Substance Registry System: 1H,1H-PERFLUOROPENTAN-1-OL(355-28-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 355-28-2(Hazardous Substances Data)

Usage

General Description

1H,1H-Perfluoropentan-1-ol is a synthetic chemical compound that belongs to the class of organic compounds known as (per)fluoroalkyl alcohols. It is characterized by its five-carbon chain which is fully fluorinated, replacing all the hydrogen atoms with fluorine atoms, and an alcohol group (-OH) attached at one end of the chain. This configuration makes the compound highly stable, non-reactive, and resistant to heat, chemical reactions, and biological degradation, which makes it suitable for various industrial applications. However, these same properties also cause the compound to persist in the environment and bioaccumulate in organisms, raising health and ecological concerns.

InChI:InChI=1/C5H3F9O/c6-2(7,1-15)3(8,9)4(10,11)5(12,13)14/h15H,1H2

Upstream product

• 2706-90-3 Perfluoropentanoic acid 
• 13038-26-1 methyl perfluoropentanoate 
• 424-36-2 2,2,3,3,4,4,5,5,5-nonafluoropentanoic acid ethyl ester 

Downstream Products

• 308-26-9 acrylic acid-(1H,1H-nonafluoro-pentyl ester) 
• 70508-50-8 Phosphoric acid bis-(2,2,3,3,4,4,5,5,5-nonafluoro-pentyl) ester phenyl ester 
• 100664-11-7 Phosphoric acid bis-(2,2,3,3,4,4,5,5,5-nonafluoro-pentyl) ester 2,2,2-trifluoro-1-m-tolyl-ethyl ester 
• 70508-49-5 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester phenyl ester 
• 375-53-1 perfluoropentanal 
• 183997-44-6 1-Nitro-4-(2,2,3,3,4,4,5,5,5-nonafluoro-pentyloxy)-benzene 
• 125888-91-7 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 125888-92-8 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester 2,2,2-trifluoro-1-(3-trifluoromethyl-phenyl)-ethyl ester 
• 1384267-34-8 C₁₇H₁₉F₉N₂O 
• 1415681-36-5 N-(2,2,3,3,4,4,5,5,5-nonafluoropentyl 11-undecanoate)-N’,N”-di(n-decyl)benzene-1,3,5-tricarboxamide 
• 883499-79-4 2,2,3,3,4,4,5,5,5-nonafluoropentyl 4-methylbenzenesulfonate 

Relevant articles and documents

Incorporation of a 3-(2,2,2-Trifluoroethyl)-γ-hydroxy-γ-lactam motif in the side chain of 4-aminoquinolines. Syntheses and antimalarial activities

In this paper we report the synthesis and antimalarial properties of two series of fluoroalkylated γ-lactams derived from 4-aminoquinoline as potent chemotherapeutic agents for malaria treatment. These molecules obtained in several steps resulted in the identification of very potent structures with in vitro activity against Plasmodium falciparum clones of variable sensitivity (3D7 and W2) in the range of 19-50 nM with resistance indices in the range of 1.0-2.5. In addition, selected molecules (50, 51, 58, 60, 63, 70, 72, 74, 78, 81, 84, and 87) that are representative of the two series of compounds did not show cytotoxicity in vitro when tested against human umbilical vein endothelial cells up to a concentration of 100 μM. The most promising compounds (82 and 84) showed significant IC50 values close to 26 and 19 nM against the chloroquino-sensitive strain 3D7 and 49 and 42 nM against the multi-drug-resistant strain W2. Furthermore, two model compounds (50 and 70) were found to be quite stable over 48 h at pH 7.4 and 5.2. Overall, our preliminary data indicate that this class of structures contains promising candidates for further study.

Hydrophobic Effects on Photochemical and Photophysical Processes: Evidence for Aggregation of Perfluorocarbon in Aqueous-Organic Solvents

The emission spectra and photodimerization of fluorinated alkyl 2-naphthoates (NpFCn) and 9-anthrylmethyl perfluoroalkanoates (AnFCn) in aqueous-organic binary solvents have been investigated.The fluorescence spectra of NpFCn in dimethyl sulfoxide-water (DMSO-H2O) are dominated by excimer emission.Addition of long chain fluorocarbon compounds to the solution results in a reduction in the excimer emission and an enhancement of monomer emission.Selective excitation of the naphthalene moiety in the mixture solution of NpFCn and AnFCn leads to strong emission from AnFCn.Photoirradiation of NpFCn yields a 'cubane-like' photodimer with a relatively high quantum yield.All these observations suggest that hydrophobic interactions force molecules with long fluorocarbon chains to form aggregates in aqueous-organic binary solvents.