35513-00-9

Basic information

• Product Name: [(4-chlorobenzyl)oxy]acetic acid
• Synonyms: acetic acid, 2-[(4-chlorophenyl)methoxy]-
• CAS NO: 35513-00-9
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.619
• Mol File: 35513-00-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 357.1°C at 760 mmHg
• Flash Point: 169.8°C
• Density: 1.322g/cm³
• Vapor Pressure: 1.02E-05mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: [(4-chlorobenzyl)oxy]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-chlorobenzyl)oxy]acetic acid(35513-00-9)
• EPA Substance Registry System: [(4-chlorobenzyl)oxy]acetic acid(35513-00-9)

Safety Data

• Hazardous Substances Data: 35513-00-9(Hazardous Substances Data)

Usage

General Description

[(4-chlorobenzyl)oxy]acetic acid is a chemical compound with the molecular formula C9H9ClO3. It is a derivative of acetic acid, with a 4-chlorobenzyl group attached to the oxygen atom of the acetic acid molecule. [(4-chlorobenzyl)oxy]acetic acid is used in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block for the preparation of organic compounds in chemical research and industry.[(4-chlorobenzyl)oxy]acetic acid is a white crystalline solid that is soluble in organic solvents but has limited solubility in water. It is important to handle this compound with care, as it can be harmful if inhaled, ingested, or comes into contact with skin or eyes.

Upstream product

• 91427-42-8 (4-chloro-benzyloxy)-acetic acid ethyl ester 
• 79-08-3 bromoacetic acid 
• 873-76-7 para-Chlorobenzyl alcohol 
• 79-11-8 chloroacetic acid 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 13807-94-8 3-((4-chlorobenzyl)oxy)propane-1,2-diol 

Downstream Products

• 88920-31-4 p-chlorobenzyloxymethyl p-chlorobenzyloxyacetate 

Relevant articles and documents

Glycerol conversion to high-value chemicals: The implication of unnatural α-amino acid syntheses using natural resources

Glycerol derivatives are an important class of compounds, which have great applications as basic structural building blocks in organic synthesis. O-Benzylglycerol was oxidised to produce a high-value compound in high yield using a NaOtBu-O2 system. Furthermore, the synthetic utility of the resulting product was demonstrated by its transformation into unnatural α-amino acids, thus showing the valorisation of glycerol biomass.

Practical preparation of benzyloxyacetic acids

An efficient and practical method for the preparation of benzyloxyacetic acids is described. The procedure involves the reaction of readily available chloroacetic acid with benzyl alcohol in the presence of powdered KOH providing a safer alternative to the known literature procedures, which completely eliminates the use of pyrophoric bases such as sodium hydride and sodium metal.

Photolysis of Alkoxyacetic Acids in the presence of Mercury(II) Oxide and Iodine

Homolytic decarboxylation of a series of alkoxyacetic acids has furnished alkoxyalkyl alkoxyacetates when no substituents were present at the 2-position.Electron donating and withdrawing 2-substituents, with the exception of trichloromethyl, afforded products due to fragmentation of the alkoxyacetic acids.The reaction pathway is rationalised on the basis of the reactivity of the alkoxyalkyl iodide intermediates.